background: microorganisms that cause early neonatal sepsis are usually already colonized rectovaginal area in mothers. the most common of these organisms is group b streptococci (gbs) and intestinal gram-negative bacteria mostly escherichia coli (e.coli). the use of prophylactic antibiotics against gbs has increased in recent years. this study aimed to determine the current situation and frequ...

Fatal sepsis during chemotherapy-induced neutropenia is the most severe complication of which physicians must be keenly aware. Common bacterial pathogens in neutropenic patients usually include gram-positive cocci such as coagulase-negative staphylococci, Staphylococcus aureus, Enterococcus species, and gram-negative rods such as Escherichia coli, Klebsiella species, Enterobacter species, and P...

Sepsis is one of the leading causes of deaths, and rapid identification (ID) of blood stream infection is mandatory to perform adequate antibiotic therapy. The advent of MALDI-TOF Mass Spectrometry for the rapid ID of pathogens was a major breakthrough in microbiology. Recently, this method was combined with extraction methods for pathogens directly from positive blood cultures. This review sum...

1. Abstract 2. Introduction 3. RAGE: expression and putative functions 4. RAGE: a receptor with multiple and diverse ligands 4.1. Putative RAGE ligands during infection 4.1.1. HMGB1 4.1.2. S100A12 4.1.3. β2 integrins 5. Soluble RAGE (sRAGE) 6. RAGE signaling 7. RAGE and infectious diseases 7.1. RAGE and abdominal sepsis 7.2. RAGE and pneumonia 7.2.1. RAGE expression during pneumonia 7.2.2. RAGE...

Methods We studied the role of these biomarkers with clustered gram-positive and gram-negative bacteremia in patients hospitalized in Intensive care Unit over a period of 2 years (2011-2013), they were measured within the 24 hours after the onset of severe sepsis or septic shock. The PCT was analyzed by immunoassay (Vidas, Brahms), lactate and CRP was measured in DIMENSION RXL SIEMENS and blood...

BACKGROUND This study aimed to summarize common pathogens and associated drug resistance in neonatal sepsis (NS). METHODS Blood culture and drug sensitivity results from 96 NS cases treated from January 2010 to August 2014 were retrospectively analyzed. RESULTS A total of 97 pathogenic bacteria were detected from these 96 NS cases; Gram-positive cocci accounted for 76.3% of the cases, among...

Sepsis caused by gram positive and gram negative bacteria is the leading cause of death in noncoronary ICUs and the tenth leading cause of death in the United States. We have developed a microfluidic sample preparation platform for rapid on-chip detection of infectious organisms for point-of-care diagnostics. The microfluidic chips are made of a robust thermoplastic and can be easily multiplexe...

ADVANCES IN SEPSIS Vol 1 No 3 2001 87 Definition and epidemiology Septic shock is defined as acute circulatory failure occurring in the presence of severe infection. In essence, this circulatory shock represents an imbalance between the body’s oxygen demands and the available oxygen supply, and is principally of the distributive type, although cardiogenic and hypovolemic components may also be ...

Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet-bacterium interactions might contribute to some of these conditions; however, mechanisms of human platelet activation by E. coli leading to thrombus formation are poorly understood. While the IgG receptor FcγRIIA has a key role in platelet respon...

Neonatal sepsis is a life-threatening emergency, and any delay in treatment may cause death. Because of the importance of the problem in Iran, the aim of this retrospective study was to determine the etiological agents of neonatal septicemia, and the prevalence and epidemiology of Klebsiella bacteremia in the neonatal wards. Two hundred and ten cases of neonatal sepsis occurred during the study...