Here, we present the case of an adolescent with a rare metastatic Inflammatory myofibroblastic tumor (IMT) harboring TFG-ROS1 fusion initially detected on progression and retrospectively identified in primary after targeted RNA sequencing. The patient benefitted from sequential TKIs over 5-year period response to third generation ALK/ROS inhibitor, lorlatinib leading resection tumor. Detailed m...

Background: Epilepsy is the 2nd greatest prevalent brain ailment after stroke, and a huge load on health system. Currently available antiepileptic drugs are associated with a lot of adverse effects and exhibit erratic pharmacological effects; hence it is crucial to explore newer anticonvulsant medications having better side effect profile and enhanced pharmacological effects because of the leng...

TrustedFlowTM is a software solution to the problem of remotely authenticating code during execution. A continuous flow of idiosyncratic signatures assures that the software from which they have emanated is not changed prior to and during execution. TrustedFlowTM can be used to create a run-time trust relationship between the components of a distributed management system. Software, especially i...

One of the most important challenges in contemporary oncology is to find objective biomarkers of tumor aggressiveness, which help to identify more invasive phenotypes of the carcinoma. The purpose of this study was to investigate the relationships between the early and the late activation markers expression on T CD4(+) and CD8(+) cells subpopulations and certain clinicopathological characterist...

Diabetes mellitus is caused due to deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. It is a global problem and number of those affected is increasing day by day. The plants provide a potential source of hypoglycemic drugs because many plants and plant derived compounds have been used in the treatment of diabetes. Several medicinal plants ha...