In the recent years, application of nanoparticles in diagnosis and treatment of cancer has been the issue of extensive research. Among these studies some have focused on the dose enhancement effect of gold nanoparticles (GNPs) in radiation therapy of cancer. On the other hand, some studies indicated energy dependency of dose enhancement effect, and the others have studied the GNP size effect in...

The synthesis and biomedical application of noble metal nanoparticles specially gold nanoparticles (GNPs) is a promising field of research and has garnered the attention of vast groups of researchers. Bulk metallic gold (Au) is known to be chemically inert. However, when the size of gold is reduced to nanometer ranges it starts to show diverse biological properties [1]. GNPs find application in...

We present a new method of rapid sequence-selective microRNA (miRNA) detection with small amount of sample using power-free PDMS microfluidic device and gold-nanoparticles (GNPs). Target miRNA hybridized to probe DNA was labeled by DNA-coated GNPs, which also act as signal amplifiers. This method allows us to detect miRNA of certain sequence in 30 min with 0.5 μL sample volume. This method migh...

Background: Normoxic type MAGICA gel dosimeters are established for dose quantification in three dimensions for radiotherapy. Objective(s): The ability of MAGICA polymer gel was assessed by experimental measurements method for studying the effect of gold nanoparticles (GNPs) in dose enhancement under the external 18MV radiotherapy practices. <...

Since the existence of nanoparticles in our environment has already attracted considerable attention due to their possible toxic impact on biological systems, the field detection of nanoparticles is becoming a technology that will be much in need. We have constructed a piezoelectric sensor with an antibody-coated electrode. The antiserum can bind gold nanoparticles with a high degree of selecti...

A simple and accurate label-free amperometric immunosensor for α-fetoprotein (AFP) detection is developed based on gold nanorods (GNRs) with different aspect ratio and compared with gold particles (GNPs). The positively charged GNRs and GNPs due to the surface immobilized cetyltrimethyl ammonium bromide (CTAB) can adsorb the negatively charged AFP antibody (Ab) directly. The presence of the GNR...

The gold nanoparticle (GNP) aggregation growth induced by deoxyribonucleic acid (DNA) is studied by laser scanning confocal and environmental scanning electron microscopies. As in the investigated case the direct light scattering analysis is not suitable, we observe the behavior of the fluorescence produced by a dye and we detect the aggregation by the shift and the broadening of the fluorescen...

Introduction: Many study shown the effectiveness dose enhancement with gold nanoparticles (GNPs), especially with low-energy x-rays. Recently, proton beam radiation therapy (PBRT) has attention as a treatment for tumors. The advantage in PBRT, which releases high dose at the controllable Bragg peak position that localized for Au target and the released dose increased in depth....

We measured the flexibility of Fab and Fc arms of immunoglobulin using gold nanoparticles (GNPs). Enzyme-linked immunosorbent assay was performed to measure the affinity of anti-5 nm GNP antiserum against various sizes of GNPs. The flexibility of Fc was also measured by electron microscopy. The restricted binding affinity indicated that only a very limited amount of freedom was allowed for the ...

In this article, a facile strategy is developed to synthesize a nanocomposite containing both a rare earth doped upconversion nanoparticle (RE-UCNP) and gold nanoparticles (GNPs). Such a nanocomposite can serve as a dual-modal imaging agent for upconversion luminescence (UCL) imaging and photoacoustic tomography (PAT). High spatial resolution, 3-dimensional imaging of blood vessels could be ach...