نتایج جستجو برای: gm1

تعداد نتایج: 1944  

2011
Nortina Shahrizaila Nobuhiro Yuki

Molecular mimicry between self and microbial components has been proposed as the pathogenic mechanism of autoimmune diseases, and this hypothesis is proven in Guillain-Barré syndrome. Guillain-Barré syndrome, the most frequent cause of acute neuromuscular paralysis, sometimes occurs after Campylobacter jejuni enteritis. Gangliosides are predominantly cell-surface glycolipids highly expressed in...

Journal: :The Journal of biological chemistry 1988
S C Li S Sonnino G Tettamanti Y T Li

We have studied the substrate specificities of a non-specific activator protein on the enzymatic hydrolyses of the following compounds: GM1 and GM2, as well as several of their derivatives including oligosaccharides, GgOse3Cer-II3-sulfate and LacCer-II3-sulfate, Gb-Ose3Cer and GbOse4Cer, three neolacto-series glycosphingolipids, and two non-ceramide glycolipids. Our results show that this activ...

Journal: :Acta neurobiologiae experimentalis 1990
M Skup M Gradkowska

Bilateral transection of the lateral fimbria, which disrupts partially the septo-hippocampal projections and results in partial hippocampal denervation, produced a significant increase in the ornithine decarboxylase (ODC) activity in the hippocampus. An increase occurred already 0.5 h after the operation and the activity remained intensified for at least 22 h after injury. The enzyme response w...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1995
G Wu Z H Lu R W Ledeen

Neuro-2a neuroblastoma cells can be stimulated to extend neurites with a number of agents, one of which, neuraminidase, induces terminal differentiation by a mechanism involving enhanced Ca2+ influx. Permeabilization of such differentiated cells with saponin and treatment with cholera toxin B subunit linked to horseradish peroxidase revealed intense staining of the nuclear membrane, indicating ...

Journal: :Journal of cell science 2002
Irina Majoul Tobias Schmidt Maria Pomasanova Evgenia Boutkevich Yuri Kozlov Hans-Dieter Söling

Cholera and Shiga toxin bind to the cell surface via glycolipid receptors GM1 and Gb3, respectively. Surprisingly, the majority of Vero cells from a non-synchronized population bind either Cholera or Shiga toxin but not both toxins. The hypothesis that the differential expression of toxin receptors is regulated by the cell cycle was tested. We find that Cholera toxin binds preferentially in G0/...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2011
Annia H Kycia Jingpeng Wang A Rod Merrill Jacek Lipkowski

The surface of a gold electrode was functionalized with a hydrophilic monolayer of 1-thio-β-D-glucose formed by spontaneous self-assembly. The Langmuir-Blodgett/Langmuir-Schaefer (LB/LS) method was then used to assemble a bilayer onto the modified Au(111) surface. The bilayer lipid membrane (BLM) was separated from the Au(111) electrode surface by incorporating the monosialoganglioside GM1 into...

2005
Gusheng Wu Zi-Hua Lu Jianfeng Wang Yvette Wang Xin Xie Markus F. Meyenhofer Robert W. Ledeen

Knock-out (KO) mice lacking gangliotetraose gangliosides attributable to disruption of the gene for GM2/GD2 synthase [GalNAcT (UDP-N-acetylgalactosamine:GM3/GD3 -1,4-N-acetylgalactosaminyltransferase; EC 2.4.1.92)] are revealing key neural functions for the complex gangliosides of brain. This study has found such animals to be highly susceptible to kainic acid (KA)-induced seizures in terms of ...

2010
J. Patrick van der Voorn Petra J.W. Pouwels Wout Kamphorst James M. Powers Martin Lammens Frederik Barkhof Marjo S. van der Knaap

Background and purpose: Radially oriented hypointense stripes in hyperintense cerebral white matter are recognized on T2-weighted images of certain lysosomal storage disorders. We compared in vivo and postmortem MR imaging findings with histopathologic findings in three patients with metachromatic leukodystrophy (MLD), globoid cell leukodystrophy (GLD) and infantile GM1 gangliosidosis (GM1) to ...

Journal: :Journal of lipid research 2005
J L Kasperzyk A d'Azzo F M Platt J Alroy T N Seyfried

II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain. In this study, we investigated the effects of N-butyldeoxygalacto-nojirimycin (N B-DGJ), an imino sugar tha...

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