the activity of cytochrome p450 isozyme 3a4 (cyp3a4) enzyme and p-glycoprotein (p-gp) is modulated by grapefruit juice and herbal drugs. cyp3a4 is the major phase i drug metabolizing enzyme and p-gp is an atp-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. honey is commonly consumed as a dietary supplement. however, its influence on human cyp3a4...

Thymus leukemia (TL) alloantigenic activity was solubilized by papain proteolytic digestion from intact RADA1 tumor cells. If the cells were labeled with amino acids and fucose, the TL alloantigen could be isolated as a doubly labeled glycoprotein fragment by indirect precipitation from the papain digest. This TL glycoprotein fragment was approximately the same mol wt as the papain-digested H-2...

Brassica vegetables are very important to human beings. Self-incompatibility (SI) is a common phenomenon in Brassica. Breeding by SI lines an way utilize heterosis of vegetables. It believed that the inheritance species controlled three linkage genes on S-locus, including SRK (S-locus receptor kinase), SCR cystine-rich protein)/SP11 protein 11), and SLG glycoprotein). female determinant SCR/SP1...

The SARS-CoV-2 virus has been responsible for a global pandemic which caused millions of deaths. Still, novel antiviral agents have investigated against SARS-CoV-2. In this view, molecular docking simulations could be used evaluating possible to tested in further experimental runs. Hence, the aim research was evaluate interaction dihydromyricetin DHM Spike glycoproteins pristine and its Delta O...

The demand for aquaculture is increasing, but production declining due to high feed costs and disease outbreaks. Viral hemorrhagic septicemia (VHS) a viral that seriously affects seawater freshwater fish in aquaculture, including the olive flounder (Paralichthys olivaceus), major Korea. However, very few vaccines are currently available virus (VHSV). nutrient-rich microalga Chlorella vulgaris h...

conclusions real-time pcr and elisa showed high levels of production of 1a/jfh1 chimeric hcv in the huh7.5 cell culture. the constructed virus can be used for future studies, including the development of new hcv drugs and vaccines. background the e2 glycoprotein is an important encoded hepatitis c virus (hcv) protein that contains three different variable regions. objectives the aim of the pres...

hepatitis c virus (hcv) envelope glycoprotein-2 (e2) inhibits the interferon (ifn)–induced, double –stranded rna activated protein kinase (pkr) via pkr eukaryotic initiation factor-2α phosphorylation homology domain (pephd). present study examined the genetic variability of the pephd in patients receiving interferon therapy. the pephd region from hcv genotype 1a/1b infected patients receiving i...