In this study, we show that an inhibitor of glycosphin-golipid biosynthesis, D,L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), increases the chemosensitivity of neuroblastoma tumor cells for Taxol and vincristine. At noneffective low doses of Taxol or vincristine, the addition of a noneffective dose of PDMP resulted in 70% cytotoxicity, indicating synergy. Such an effect was no...

In spite of its long history, immunotherapy of cancer has led to only a few regulatory approved treatments, starting with interleukin (IL)-2 in renal cancer and melanoma and interferon in melanoma. Sipuleucel-T was approved for castrateresistant prostate cancer in 2010 and ipilimumab and pegylated interferon-α2b in 2011 for the treatment of metastatic and adjuvant melanoma respectively. Evidenc...

The acute phase response (APR) is accompanied by major changes in micronutrient status. It is important to be able to quantitate the degree of APR, which can then be related to the accompanying alterations in micronutrient levels. A rapid and convenient means of achieving this, viz. the use of an animal model in which APR can be induced, would facilitate such an investigation. The aim of the pr...

OBJECTIVES To identify the characteristics of patients with acute coronary syndromes (ACS), their hospital management and in-hospital outcomes, through a prospective registry system in Kuwait. SUBJECTS AND METHODS A registry involving all 7 general hospitals in Kuwait was set up. Consecutive patients diagnosed as having ACS over a period of 6 months were enrolled. RESULTS Of 2,129 patients ...

The recombinant human (rh) myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) model in the common marmoset is characterized by 100% disease incidence, a chronic disease course, and a variable time interval between immunization and neurological impairment. We investigated whether monkeys with fast and slow disease progression display different anti-...

Glucose-regulated protein 94 (GRP94/gp96), the endoplasmic reticulum heat shock protein 90 paralog, elicits both innate and adaptive immune responses. Regarding the former, GRP94/gp96 stimulates APC cytokine expression and dendritic cell maturation. The adaptive component of GRP94/gp96 function reflects a proposed peptide-binding activity and, consequently, a role for native GRP94/gp96-peptide ...

Background: Thalassemia is the most common cause of chronic hemolytic anemia and correlated with significant morbidity mortality. Osteoprotegerin (OPG) an ? tumor necrosis factor receptor superfamily glycoprotein that acts as a decoy for activator nuclear kappa B ligand (RANKL), exerting antiresorptive bone effect also play critical roles in hypogonadism associated osteoporosis. Objective: Toe...

The membrane glycoprotein CD36 is involved in platelet aggregation, inhibition of angiogenesis, atherosclerosis, and sequestration of malaria-parasitized erythrocytes. In this study, immunoprecipitations with anti-CD36 antibodies were performed to identify proteins that associate with CD36 in the platelet membrane. Platelets were solubilized in 1% Triton X-100, 3-[(3-cholamidopropyl)dimethylamm...

ischemic stroke accounts for about 87 percent of all cases. it occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. it is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. we know that most of the injuries after an acute ischemic s...