نتایج جستجو برای: glycomics
تعداد نتایج: 801 فیلتر نتایج به سال:
Glycans play a critical role in physiological and pathological processes through interaction with a variety of ligands. Altered expression and dysregulation of these molecules can cause aberrant cellular function such as malignancy. Glycomics provide information of the structure and function of glycans, glycolipids, and glycoproteins such as proteoglycans, and may help to predict cancer develop...
Recent advances in biology have afforded scientists with the knowledge that polysaccharides play an active role in modulating cellular activities. Glycosaminoglycans (GAGs) are one such family of polysaccharides that play a very important role in regulating the functions of numerous important signaling molecules and enzymes in the cell. Developing bioinformatics tools has been integral to advan...
We developed a 3 h procedure for preparing serum N-glycans and labeling them with 8-aminopyrene-1,3,6-trisulfonic acid (APTS) by sequential addition of reagents to the serum and incubation in a polymerase chain reaction (PCR) thermocycler. Moreover, we succeeded in analyzing these samples by capillary electrophoresis on three commercial microfluidics-based platforms: the MCE-202 MultiNA, the 21...
Carbohydrates are involved in a variety of fundamental biological processes, e.g. cellular differentiation, embryonic development or fertilization. Since glycans are secondary gene products and their structure cannot be easily predicted from DNA sequences, very little of the bioinformatics algorithm and techniques developed for genomics and proteomics research can be directly adapted for glycom...
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