Mammalian embryos transiently exhibit aerobic glycolysis (Warburg effect), a metabolic adaptation also observed in cancer cells. The role of this particular type of metabolism during vertebrate organogenesis is currently unknown. Here, we provide evidence for spatiotemporal regulation of glycolysis in the posterior region of mouse and chicken embryos. We show that a posterior glycolytic gradien...

THE effect of rise in temperature on the respiration and glycolysis of animal tissues has been studied by Kubowitz [1929] and by Nakashima [1929]. Kubowitz using frog retina showed that aerobic glycolysis suddenly becomes apparent above 35°. The Pasteur effect is abolished above this temperature since the Meyerhof quotient descends to zero. Nakashima employed fish retina, which, like amphibian ...

Neurons in the ventromedial hypothalamus mediate some counterregulatory responses to hypoglycemia and 2-deoxyglucose, but the mechanisms that mediate these responses to glucose are unclear. In the present study, ventromedial hypothalamus neurons were identified on the basis of their inhibition by the transition from 5 to 20 mmol/l glucose. Tolbutamide, which activates glucose-stimulated neurons...

Inflammation is a constant in Non-Alcoholic Fatty Liver Disease (NAFLD), although their relationship unclear. In transgenic zebrafish system with chronic systemic overexpression of human IL6 (IL6-OE) we show that inflammation can cause intra-hepatic accumulation triglycerides. Transcriptomics and proteomics analysis the IL6-OE liver revealed deregulation glycolysis/gluconeogenesis pathway, espe...

TH9 cells, a subpopulation of TH2 are crucial mediators allergic skin inflammation. They characterized by expression IL-9/IL-9R and rely on the transcription factor PPARγ for full effector function. The functional role in however, remains unknown. Pathway analysis RNA-seq data from PPARγ-inhibited cells revealed concerted downregulation genes associated with T cell activation, glucose metabolis...