PURPOSE Insulin resistance is thought to be a core defect in the pathophysiology of obesity-related comorbidities in children, such as type 2 diabetes. Exercise training is known to improve insulin resistance and reduce the risk of type 2 diabetes in adults. However, very little is known regarding the effects of exercise on insulin resistance in youth. Therefore, we examined the effects of a 16...

Objective. Succnic acid mono ethyl ester (EMS) was recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study the effect of EMS and Metformin on the activities of carbohydrate metabolic enzymes in streptozotocinnicotinamide induced type 2 diabeteic model was investigated. Methods. EMS were injected intraperitonially at doses 2...

OBJECTIVE Mitochondrial dysfunction and fat accumulation in skeletal muscle (increased intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes. We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Eighteen male type 2 diabetic and 20 healthy male control subjec...

the aim of this study was to investigate the effect of eight weeks of aerobic training along with milk supplement on glut4, glucose and insulin in overweight immature boys. for this purpose, 28 immature overweight boys (8 to 10 years) were selected according to the questionnaire of nutrition, exercise abilities, body mass index, health and welfare from volunteers. then, subjects were divided in...

the aim of the present study was to investigate the effect of two aerobic training programs with different intensities on some cardiovascular risk factors in young girls. for this purpose, 42 girls (mean age 20.59±1.46 years, height 160.29±4.75 cm, weight 59.23±8.82 kg, bmi 22.08±3.41 kg/m2, %bf 15.42±3.85 and vo2max 25.34±3.96 ml/kg/min) were voluntarily participated in this study and divided ...

Most resistance training studies of older subjects have emphasized low-intensity, short-term training programs that have concentrated on strength measurements. The purpose of this study was, in addition to the determination of strength, to assess intramuscular and transport factors that may be associated with strength increments. Eighteen untrained men ages 60-75 years volunteered for the study...

results serum estradiol levels tended to have a negative correlation with homeostasis model assessment of insulin resistance (homa-ir) in premenopausal women but not in postmenopausal women. on the other hand, free testosterone levels tended to have a positive correlation with homa-ir in postmenopausal women but not in premenopausal women. serum shbg levels showed significant negative correlati...