نتایج جستجو برای: glycoconjugates
تعداد نتایج: 2053 فیلتر نتایج به سال:
Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glycosylated peptide therapeutics. Furthermore, the impacts of glycosylation in overcoming the existi...
All cells are coated in carbohydrates and glycoconjugates. Today, after decades where sugars were regarded mainly as a means of energy storage or simply as molecular material, it is now known that carbohydrates are deeply involved in cellular communication. This awareness of the biological importance of carbohydrates has led to glycosciences becoming an intriguing and fascinating field of inter...
In this communication we report for the first time the use of azobenzene modified glycoconjugates to establish optical control over bioactive ligands at a supramolecular β-cyclodextrin (β-CD) surface. Several studies were conducted to investigate the photoresponsive immobilization of proteins and bacteria on these supramolecular surfaces.
Glycosyltransferases, the enzymes that build oligosaccharides and glycoconjugates, have received much interest in recent years owing to their biological functions and their potential uses in biotechnology. Despite the fact that many glycosyltransferases recognize similar donor or acceptor substrates, there is surprisingly limited sequence identity between different classes. On the one hand, the...
Lectin, a word of Latin origin, is a substance which is not triggered by antigenic stimulations in the immune system and which combines with an antigen in a way resembling that of an antibody. Accordingly, it can be described as a substance which can agglutinate cells or precipitate glycoconjugates, with a structure resembling a carbohydrate binding protein or glycoprotein and is not of immune ...
Multivalency effects are essential in carbohydrate recognition processes as occurring on the cell surface. Thus many synthetic multivalent glycoconjugates have been developed as important tools for glycobiological research. We are expanding this collection of molecules by the introduction of carbohydrate-scaffolded divalent glycothymine derivatives that can be intramolecularily dimerized by [2 ...
In the realm of chemical synthesis, a child envisioned an adventurous journey manganese(I) catalysis full obstacles, like distant howls wolves echoing through night, with ultimate goal finding general route to discover linear, selective C−H dienylation method that leads electron-rich and electron-poor dienes, glycoconjugates, unnatural amino acids. The synthetic application this is also eased d...
There has been increasing interest in the construction of liposomes containing a targeting reagent for target-specific drug delivery. Glycoconjugates that can be recognized by transmembrane glycoprotein receptors have been extensively used to form glyco-liposomal drug carriers. However, the impact of anomerism, which is a common identity of natural glycoconjugates, on the glyco-liposomal proper...
Four different types of lectin were applied to the rabbit conjunctiva and the lacrimal sac to examine the distribution of glycoconjugates. The conjunctival epithelium is comprised of goblet cells and nongoblet cells. The mucus granules of the goblet cells were stained with soybean agglutinin (SBA), and the cell body of the nongoblet cells was labeled with concanavalin A (Con A). The glycocalyx ...
Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for study...
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