The treatment of pain in acute myocardial infarction varies with local practice. Narcotic analgesics are still the usual treatment in many hospitals. Knowledge of optimal doses, duration of pain relief, and time between drug administration and pain relief is inadequate. Many studies indicate that the relief of pain is often incomplete after' treatment with narcotic analgesics. There is often a ...

Verapamil is a slow calcium channel blocker that has been in clinical use for almost 20 years as an antiarrhythmic agent. It also has an antianginal action,' but inconsistent results have been obtained in clinical trials owing to insufficient dosage.2 We found that the drug produced a significant decrease in the number of anginal attacks and the consumption of glyceryl trinitrate with improveme...

The treatment of pain in acute myocardial infarction varies with local practice. Narcotic analgesics are still the usual treatment in many hospitals. Knowledge of optimal doses, duration of pain relief, and time between drug administration and pain relief is inadequate. Many studies indicate that the relief of pain is often incomplete after treatment with narcotic analgesics. There is often a n...

described, but in our two patients there was no other obvious cause for this condition. At the time of their admission for myocardial infarction both patients had taken diamorphine, prochlorperazine, and glyceryl trinitrate; one patient (case 1) also took a few doses of frusemide and cyclopenthiazide, and the other required co-proxamol and buprenorphine intermittently over the first few days. N...

Glyceryl trinitrate (GTN) is a potent vasodilator. It causes venodilatation which reduces venous return to the heart and thus reduces preload and also causes arterial vasodilatation which reduces left ventricular afterload. In angina pectoris these effects reduce myocardial wall tension and thereby reduce myocardial oxygen consumption and arterial vasodilatation increases myocardial oxygen deli...

A Phase I, double-blind, randomized, crossover study in healthy males (N=106) was conducted between March 21, 2004, and May 17, 2004, to determine the magnitude and duration of the hemodynamic interaction of avanafil (a phosphodiesterase type-5 inhibitor for treating males with erectile dysfunction) when coadministered with glyceryl trinitrate (NTG) compared with sildenafil and placebo. Subject...