The present study was undertaken to investigate the antioxidant potential of ethanolic extracts of four fruits Indian gooseberry, mango, star fruit and wood apple on the oxidative changes in hepatic tissue exposed to sodium fluoride in vitro. Liver homogenates were exposed to NaF and subsequently treated with ethanolic extracts of fruits and the levels of antioxidants (ascorbic acid, superoxide...

Cellular defense against excessive peroxynitrite generation is required to protect against DNA strand-breaks and mutations and against interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine. We recently demonstrated a role of selenium-containing enzymes catalyzing peroxynitrite reduction. Glutathione peroxidase (GPx) protected against ...

Two glutathione peroxidase (GPX) isozymes, GPX-1 and GPX-2 (GPX-GI), are the major enzymes that reduce hydroperoxides in intestinal epithelium. We have previously demonstrated that targeted disruption of both the Gpx1 and Gpx2 genes (GPX-DKO) results in a high incidence of ileocolitis in mice raised under conventional conditions, which include the harboring of Helicobacter species [non-specific...

A series of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives has been synthesized. The glutathione peroxidase like catalytic activity of these compounds has been studied in a model system, in which reduction of hydrogen peroxide with dithiothreitol (DTT(red)), in the presence of an organoselenium compound was investigated by (1)H NMR spectroscopy. All these compounds exhibit GPx like catalyt...

Methods Male wistar rats were randomly divided into three groups. Group 1 (n=5) received no supplementation and served as the control while group 2 (n=6) and 3 (n=6) received 2ml and 4ml red palm oil (RPO), respectively. Plasma total polyphenols, plasma antioxidant capacity [i. e. oxygen radical absorbance capacity (ORAC)], ferric reducing antioxidant power (FRAP) as well as levels of antioxida...

Cellular glutathione peroxidase (GPx-1), a selenocysteine-containing enzyme, plays a central role in protecting cells from oxidative injury. GPx-1 is ubiquitously expressed in eukaryotic cells where it reduces hydrogen and lipid peroxides to alcohols. Adenosine, which is released from stressed or injured cells, protects against ischemia/reperfusion injury and apoptosis. In this study, we hypoth...

Abbreviations: DGC, dystrophin glycoprotein complex; DAPC, dystrophin associated protein complex; β-DG, Beta-dystroglycan; ALA, Alpha-lipoic acid; L-Car, L-carnitine; CK, creatine kinase; TBARS, thiobarbituric acid reactions; SOD, superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; MyHC, myosin heavy chain; HO-1, Heme oxygenase-1; NF-κB, nuclear factor-κB; MMP, Matrix Metalloprote...

Objectives: This study aimed to investigate the effects of six-week continuous training (CT) and high-intensity interval (HIIT) protocols on brain superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) activities their associations with short-, mid-, long-term memory in albino Wistar rats. Methods: In this study, 18 male rats (5 months old) were randomly assigned three equal (...

The aim of this study was to investigate the response different doses lipopolysaccharide (LPS) and extracellular product (ECP) antigens (25, 50, 100, 250, 500 µg) obtained from Flavobacterium psychrophilum changes in oxidative stress parameters (catalase [CAT], superoxide dismutase [SOD], glutathione peroxidase [GPx], glucose 6-phosphate dehydrogenase [G6PD], reductase [GR], malondialdehyde [MD...