The concentrations of selenium and lipid peroxides and the catalytic activity of glutathione peroxidase were measured in the blood of 6 children (6-16 years of age) and 8 adults (17-27 years old) with Down's syndrome (trisomy 21). The values were compared with those for a control group of age-matched normal people. The selenium concentration in whole blood, erythrocytes and plasma was significa...

Persons afflicted with protein malnutrition are generally deficient in a variety of essential micronutrients like zinc, copper, iron, and selenium, which in turn affects number of metabolic processes in the body. To evaluate the protective effects of zinc on the enzymes involved in oxidative stress induced in liver of protein-deficient rats, the current study was designed. Zinc sulfate at a dos...

Human brain contains one cationic (pI8.3) and two anionic (pI5.5 and 4.6) forms of glutathione S-transferase. The cationic form (pI 8.3) and the less-anionic form (p1 5.5) do not correspond to any of the glutathione S-transferases previously characterized in human tissues. Both of these forms are dimers of 26 500-Mr subunits; however, immunological and catalytic properties indicate that these t...

The bacterial peroxiredoxin AhpC, a cysteine-dependent peroxidase, can be converted through a single amino acid insertion to a disulfide reductase, AhpC*, active in the glutathione and glutaredoxin pathway. Here we show that, whereas AhpC* is inactive as a peroxidase, other point mutants in AhpC can confer the in vivo disulfide reductase activity without abrogating peroxidase activity. Moreover...

Normal cellular functions essentially depend on a balanced redox environment. Free radicals and nonradical oxidants can shift the redox balance toward a more “oxidized” state, which is counteracted by the intracellular antioxidant defense systems. These include the enzymes superoxide dismutase and catalase, as well as the thiol-reducing systems (glutathione, glutaredoxin, and thioredoxin). Glut...

Abstract This review aimed to assess the antioxidant properties of safrole, myristicin, and terpineol from Myristica fragrans Houtt. Safrole exhibited high cytotoxic activities against numerous cancer cell lines also shown able suppress tumor angiogenesis. Myristicin is increase activity glutathione peroxidase (GPX), reductase (GR) or glutathione-disulfide-reductase (GSR), superoxide dismutase ...

Summary The study aimed to investigate glutathione peroxidase (GPx) activity and (GSH) levels in the sperm of patients with unexplained infertility. samples were collected from subjects normal semen parameters divided into fertile infertile groups. Sperm analysis was performed according 2010 WHO criteria. Measurement GPx GSH by enzymatic assay kits. higher recorded spermatozoa seminal plasma gr...