نتایج جستجو برای: glucose regulated protein 78kda

تعداد نتایج: 1471106  

Journal: :Frontiers in bioscience : a journal and virtual library 2003
Julian Grusovin S Lance Macaulay

Fusion of GLUT4 vesicles with the plasma membrane is a key terminal step in insulin-regulated glucose transport. This fusion event is mediated by SNARE proteins, syntaxin 4, SNAP23 and VAMP2, through a process regulated by accessory proteins whose roles are still unclear. Munc18c is a key regulatory protein of syntaxin, and possibly of whole-SNARE complex cycling. Rab GTPases, through interacti...

Journal: :the iranian journal of pharmaceutical research 0
minoo shahani department of base science, science and research branch, islamic azad university, tehran, iran. fatemeh daneshi-mehr proteomics research center, shahid beheshti university of medical sciences, tehran, iran. roya tadayon proteomics research center, shahid beheshti university of medical sciences, tehran, iran. behrooz hoseinzade salavati proteomics research center, shahid beheshti university of medical sciences, tehran, iran. ali-reza akbar zadeh-baghban faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran. abbas zamanian department of surgery, faculty of medicines, shahid beheshti university of medical sciences, tehran, iran.

human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. due to its long life period and high concentration in plasma, hsa is highly sensitive to glycation. it is reported that 175 mg/dl glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. ph denaturation of hsa in absence and presence of...

Background: Salinity is a major environmental limiting factor, which affect agricultural production. The two Manilkara seedlings (M. roxburghiana and M. zapota) with high economic importance, could not adapt well to higher soil salinity and little is known about their proteomic mechanisms. Objectives: The mechanisms responsible ...

Journal: :Journal of the American Chemical Society 2012
Adam S Duerfeldt Laura B Peterson Jason C Maynard Chun Leung Ng Davide Eletto Olga Ostrovsky Heather E Shinogle David S Moore Yair Argon Christopher V Nicchitta Brian S J Blagg

Heat shock protein 90 (Hsp90) represents a promising therapeutic target for the treatment of cancer and other diseases. Unfortunately, results from clinical trials have been disappointing as off-target effects and toxicities have been observed. These detriments may be a consequence of pan-Hsp90 inhibition, as all clinically evaluated Hsp90 inhibitors simultaneously disrupt all four human Hsp90 ...

2015
Mark A. Smith Loukia Katsouri Elaine E. Irvine Mohammed K. Hankir Silvia M.A. Pedroni Peter J. Voshol Matthew W. Gordon Agharul I. Choudhury Angela Woods Antonio Vidal-Puig David Carling Dominic J. Withers

Hypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism. However, the long-term effects of manipulating hypothalamic S6K1 signaling on energy homeostasis and the cellular mechanisms underlying these roles are unclear. We therefore inactivated S6K1 in pro-opiomelanocortin ...

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