low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...

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The effect of ethanol on the interrelationship of lactate and glucose metabolism was investigated in eight human volunteers. Lactate and glucose kinetics and intervconversion rates were determined by the sequential administration of L-(+) lactate-U-(14)C and glucose-1-(14)C over an 8 hr period. After a 12 hr fast, the glucose turnover and recycling rates were 94.0 +/-3.8 (SEM) and 13.7 +/-1.1 m...

This work was presented in part at the Southern Section, American Federation for Clinical Research, New Orleans, La., 1 February 1975, and the American Diabetes Association, New York, 17 June 1975. Dr. Raskin is a Veterans Administration Research Associate. Dr. Fujita's present address is the Fourth Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japa...

Glycemic status depicts a state of individual blood glucose level. Biochemical parameters to identify glycemic associated with diabetes mellitus include fasting or non-fasting glucose, HbA1c, and oral tolerance. Our present work conducted systematic review aiming systematically summarize the in vivo experimental results nutmeg treatments towards rats mice. The followed PRISMA guidelines. PubMed...

To determine the effect of D-glucose on the beta-cell Na+/K+ pump, 86Rb+ influx was studied in isolated, -cell-rich islets of Umeå-ob/ob mice in the absence or presence of 1mM ouabain. D-glucose (20mM) stimulated the ouabain-sensitive portion of 86Rb+ influx by 65%, whereas the ouabain-resistant portion was inhibited by 48%. The Na+/K+ ATPase activity in homogenates of islets of Umeå-ob/ob mice...

We report the effect of glucose on the expression of the gene encoding the pyruvate dehydrogenase (E1) alpha subunit (E1alpha) in human hepatoma (HepG2) cells. Total pyruvate dehydrogenase complex activity as well as the levels of protein and mRNA of the E1alpha subunit were significantly increased in HepG2 cells cultured in medium containing 16.7 mM glucose compared with 1.0 mM glucose for a p...

The phosphorylation of glucose and recycling between glucose and glucose-6-P was determined in hepatocytes from fasted rats by a novel method. The cells were incubated with [U-14C]glucose as sole substrate in media containing 3HOH and D2O. Recycling was calculated from the yield of protons in glucose and glycogen. Results with 3HOH and D2O were identical. Phosphorylation was obtained as the sum...

Background. Maximal Aerobic Power is related to many quantities and qualities such as supplements. Objectives. The purpose of the present study was to describe the effect of short-term supplementation of glutamine and glucose on hemoglobin and maximum aerobic power in female athletes. Methods. In this quasi-experimental study, 40 female athletes (age 21.9±2.6 years, height 161.8&...

Nitric oxide synthase (NOS) inhibition has been shown in humans to attenuate exercise-induced increases in muscle glucose uptake. We examined the effect of infusing the NO precursor L-arginine (L-Arg) on glucose kinetics during exercise in humans. Nine endurance-trained males cycled for 120 min at 72+/-1% Vo(2 peak) followed immediately by a 15-min "all-out" cycling performance bout. A [6,6-(2)...