Acute hemolytic anemia (AHA) due to glucose 6-phosphate dehydrogenase (G6PD) deficiency has rarely been recognized as a contributor to the development of frostbite. We discuss a case of frostbite in a 32-year-old male Marine with G6PD deficiency during military training on Mount McKinley in Alaska, which eventually led to a permanent disability. In this report, the pathophysiology of G6PD defic...

Glucose-6-phosphate (G6PD) deficiency is the most common human enzyme defect, often presenting with neonatal jaundice and/or acute hemolytic anemia, triggered by oxidizing agents. G6PD deficiency is an X-linked, hereditary disease, mainly affecting men, but should also be considered in females with an oxidative hemolysis.

People with the variants of glucose-6-phosphate dehydrogenase (GPD) deficiency common in the southern Chinese (Canton, B(-)Chinese, and Hong Kong-Pokfulam) have a moderate shortening of red-cell survival but no anaemia when they are in the steady state. With a cross-transfusion technique, primaquine, nitrofurantoin, and large doses of aspirin were found to aggravate the haemolysis while sulpham...

The enzyme, Glucose-6-phosphate dehydrogenase (G6PD), deficiency leads to impaired production of reduced glutathione and predisposes the red cells to damage by oxidative metabolites, causing hemolysis. Deficient neonates may manifest clinically as hyperbilirubinemia or even kernicterus. Screening for G6PD deficiency and recognition of prevalence of the enzyme deficiency in individual communitie...

G lucose-6-phosphate dehydrogenase (G6PD) deficiency is a common Xlinked human enzyme defect (1). There are a few reports that link G6PD deficiency to diabetes (2–4). We undertook a cross-sectional study at Maccabi Healthcare Services, an Israeli HMO serving two million members. All interactions and information are captured on an electronic medical record. Our study population included all male...

Glucose-6-phosphate dehydrogenase (G6PD, EC1.1.1.49) is expressed in all tissues where it is the first and rate-limiting enzyme of the pentose phosphate pathway (PPP) [1] that consists of the oxidative and non-oxidative branches and usually works at 1–2% of its maximal potential in healthy subjects due to the high level of nicotinamide adenine dinucleotide phosphate (NADPH). The G6PD gene is wi...

There is now evidence that an increase in the low-density serum lipoproteins plays a part in the causation of degenerative vascular disease (Gofman, Jones, Lindgren, Lyon, Elliott, and Strisower, 1950; Kannel, Dawber, Kagan, Revotskie, and Stokes, 1961). Studies of serum cholesterol in different ethnic groups has shown important differences (Adlersberg and Schaefer, 1959), but it cannot yet be ...

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T HE MEDITERRANEAN variety of glucose-6phosphate dehydrogenase (G6PD) deficiency is characterized by severely decreased catalytic activity in the affected erythrocytes and is therefore classified as belonging to class II in the usual tabulations of G6PD variants.’ However, evidence has been provided that in Mediterranean countries there are several polymorphic G6PD variants sharing activity lev...

In southern China, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a significant health problem, and the incidence ranged from 0.5 to 4.08% in different Chinese population. The aims of this study are to investigate the molecular epidemiological characteristic of the G6PD gene among Chinese Hakka in southern Jiangxi province. 2331 unrelated subjects were screened for G6PD deficiency by a ...