Haematologica vol. 85(3):March 2000 4. Mason PJ, Sonati MF, MacDonald D, et al. New glucose-6-phosphate dehydrogenase mutations associated with chronic anemia. Blood 1995; 85:1377-80. 5. Poggi V, Town M, Foulkes NS, Luzzatto L. Identification of a single base change in a new human mutant glucose-6-phosphate dehydrogenase gene by polymerase-chain-reaction amplification of the entire coding regio...

Earlier studies of the A and B allozymes at the G6pd locus show a differential ability of the genotypes to suppress the loss of viability associated with a low activity 6-phosphogluconate dehydrogenase mutation, 6Pgdlo1. This observation indicates a relatively lower activity for the A allozyme genotype, but it is not known if this level of suppression required a large difference in in vivo acti...

Any alteration in the optical homogeneity of the lens or decrease in its transparency is known as cataract. Glucose 6 phosphate dehydrogenase (G6PD) activity was measured in both erythrocytes and lenses of study groups and control groups. The decreased activity of G6PD was observed in the study group subjects both in erythrocytes and lenses when compared with controls. These results showed that...

The rates of activity of the dehydrogenase systems in Tetrahymena, which are concerned with carbohydrate oxidation, in descending order of activity are: lactic > isocitric > succinic = glucose > glucose-6-phosphate = 6-phosphogluconic = malic > glutamic = cytochrome linked alpha-glycerophosphate dehydrogenase. No evidence was obtained to indicate the presence of DPN linked alpha-glycerophosphat...

1. The effects of a 100 g/kg substitution of guar gum on the body-weight gain, food consumption and faecal dry weight of mice fed on a high-sucrose diet and on the activities of hepatic glucose-6-phosphate dehydrogenase (EC 1 . 1 . 1 .49), 6-phosphogluconate dehydrogenase (EC 1 . I . 1 .44), malate dehydrogenase (oxaloacetatedecarboxylating) (NADP+) (EC I . 1 . 1 .40), ATP-citrate (pro-3S)-lyas...

BACKGROUND AND OBJECTIVE Iron is an essential element that is necessary for all cells in the body. Iron deficiency anemia (IDA) is one of the most common nutritional disorders in both developed and developing countries. The glutathione pathway is paramount to antioxidant defense and glucose-6-phosphate dehydrogenase (G6PD)-deficient cells do not cope well with oxidative damage. The goal of this...

Abstracfi This paper describes preparations of o(and r--) chlorolactic acids having enantiomeric excesses greater than 977o by o(and l-) lactate dehydrogenase catalyzed reduction of chloropyruvic acid with NADH. In syntheses carried out on 0.1{).5-mol scales, the NADH was regenerated in situ by using glucose 6-phosphate and glucose 6-phosphate dehydrogenase. The enantiomerically enriched chloro...

This case report describes a preterm newborn infant who was treated with a single dose of rasburicase for an increase in uric acid level. He died on the third day as a result of complications of hemolysis, which appeared to be precipitated by rasburicase. The patient's death was preceded by progressive respiratory insufficiency, lactic acidosis, and hyperbilirubinemia, culminating in refractory...

1. The activities of the oxidative enzymes (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and of the non-oxidative enzymes (transaldolase, tranketolase, ribose 5 phosphate isomerase and ribulose 5-phosphate 3-epimerase) of the pentose phosphate pathway were measured at various times during the first 24h of skeletal-muscle regeneration after administration of Marcaine, ...