Glomerular development was studied in the newborn rat kidney by electron microscopy and cytochemistry. Glomerular structure at different developmental stages was related to the permeability properties of its components and to the differentiation of anionic sites in the glomerular basement membrane (GBM) and on endothelial and epithelia cell surfaces. Cationic probes (cationized ferritin, ruthen...

INTRODUCTION For at least a decade, a chronic kidney disease unassociated with diabetes mellitus, hypertension or any of the more common traditional causes, has been reported in Salvadoran agricultural communities. OBJECTIVE Characterize histopathology of chronic kidney disease of unknown etiology in patients from Salvadoran agricultural communities, describe renal damage associated with each...

Diabetic nephropathy and obesity At the Clinical Update in Diabetic Nephropathy at the American Diabetes Association Scientific Sessions, Karen A. Griffin (Maywood, IL) discussed interrelationships between obesity and the kidney, noting that obesity appears to be related to the increase in end-stage renal disease (ESRD), in part because of its relationship to diabetes and hypertension, but with...

This study presents data on some phasic EEG phenomena regulary recorded during sleep - wakefulness cycle and heterogeneity of EEG sleep stages forming consecutive human sleep macrocycles. These short-term EEG changes quite often tend to periodization, especially during initial sleep-stages and transitive states (sleep microcycles). An attempt was made to reveal EEG microstructures in sleep - wa...

Mancia G. Early sympathetic activation in the initial clinical stages of chronic renal failure. First demonstration of increased sympathetic neural discharge in mild-to-moderate renal failure. Hypertension 2011;57:846–851. 35. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev 1997;77:75–197. 36. Norvell JE, Weitsen HA, Dwyer JJ. Degeneration and regeneration of adrenergic nerves...

Nearly ten years ago Nephrologists began using asystem of classification for chronic kidney disease (CKD). This was established in 2002 by the Kidney Disease Outcome Quality Initiative (KDOQI) to estimate kidney function in a given patient regardless of the etiology of the primary insult to the kidneys. Physicians were able place their patients in stages from mild disease to end stage renal dis...

Vitamin D deficiency is associated with various medical conditions including musculoskeletal disorders, infection, metabolic diseases, and cardiovascular disease. Megalin and cubilin, endocytic receptors in proximal tubule cells, are involved in the reabsorption of vitamin D binding protein from glomerular filtrates and the subsequent intracellular conversion of 25-hydroxyvitamin D(3) to biolog...

Abslract-This article presents a self-organizing model of convergence for the early stages of the olfactory pathway. The model generates a chemotopic projection from olfactory receptor neurons onto glomeruli based on receptor aflinity distributions. The resulting glomerular images reveal an olfactory code consistent with neurobiology, whereby odor quality is encoded by a unique spatial pattern ...

BACKGROUND Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed. METHODS From a community-based sample of 4,409 individuals residing in a well-defined geographical area, we determined the number of patients having a first serum ...