The recent article about estimated glomerular filtration rate (GFR) by Levey and colleagues (1) is remarkable. The authors suggest that the new equation may still have some bias and especially may have less precision in patients with GFRs greater than 60 mL/min per 1.73 m 2 . This is even more important if the GFR is greater than 90 mL/min per 1.73 m 2 . In the paper's Methods section, Levey an...

The occurrence of chronic kidney disease is underestimated in both human and veterinary medicine. Glomerular filtration rate (GFR) is considered the gold standard for evaluating kidney function. However, GFR assessment is time-consuming and labor-intensive and therefore not routinely used in practice. The commonly used indirect GFR markers, serum creatinine (sCr) and urea, are not sufficiently ...

To evaluate renal functions in camel, the study on profiles like Serum Creatinine (SC), Serum urea nitrogen (SUN), SUN/SC ratio was undertaken in institute’s herd of camels (n=250) (Camelus dromedarius) of all age groups, both sexes and three breeds and in addition Glomerular Filtration rate (GFR) of 18 male camels of 3 breeds (n=6 each) with 6 individual replicates (Total 108 observations) wer...

Background: Glomerular filtration rate (GFR) is the most widely used indicator of kidney function although it does not invariably reflect the functional status after renal injury. The concept of renal function reserve (RFR) as the ability of the kidney to increase GFR following a protein load was introduced in 1980s. In hydronephrotic children, the acute hemodynamic response to intravenous prot...

Glomerular and tubulo-interstitial lesions are involved in the determination of the degree of renal function impairment and in the outcome of the disease in patients with primary or secondary glomerulonephritis. In order to assess the histological changes we used a scoring system, similar to the one used in lupus nephritis and ANCA associated vasculitis. The scores obtained from the retrospecti...

Creatinine-based glomerular filtration rate estimation (eGFRcr) has been improved and refined since the 1970s through both the Modification of Diet in Renal Disease (MDRD) Study equation in 1999 and the CKD Epidemiology Collaboration (CKD-EPI) equation in 2009, with current clinical practice dependent primarily on eGFR for accurate assessment of GFR. However, researchers and clinicians have rec...

Heightened sensitivity of the diabetic proximal tubule to dietary salt leads to a paradoxical effect of salt on glomerular filtration rate (GFR) via tubuloglomerular feedback. Diabetic hyperfiltration is a feedback response to growth and hyperreabsorption by the proximal tubule. The present studies were performed to determine whether growth and hyperfunction of the proximal tubule are essential...

OBJECTIVE To investigate the relationship of creatinine and calculated glomerular filtration rate (GFR) with coronary arterial disease (CAD) in Pakistani patients. SUBJECTS Four hundred individuals with chest pain; 200 with angiographic disease matched with 200 without occlusive disease. DESIGN A prospective case-control study. SETTING A tertiary referral cardiology unit in Pakistan. RE...

BACKGROUND An accurate estimation of renal function in children is important in optimising the dose of many drugs used in paediatric oncology for allowing clinical monitoring of the nephrotoxic effects of cytotoxic agents such as cisplatin. The glomerular filtration rate (GFR) is widely accepted as the best index of renal function in patients. Chemotherapy is the mainstay of treatment in the pa...

Introduction:Detecting renal allograft dysfunction early will allow timely diagnosis and treatment. There is no objective recommendation by national kidney societies for glomerular filtration rate (eGFR) estimation in post-transplant setting. 99mTc-DTPA Technetium-99m Diethylene triamine penta acetic acid) renogram can identify early renal dysfunction much before ser...