Despite the development of several pharmacological agents over the past decade, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and sodium glucose cotransporter 2 (SGLT2) inhibitors, the management of hyperglycaemia in patients with type 2 diabetes remains challenging. SGLT2 inhibitors are a new class of glucose-lowering agents that have a u...

Several new oral drugs have been approved for the management of type II diabetes. Metformin is an "antihyperglycemic agent" that decreases hepatic glucose production and improves insulin sensitivity. It may be used as monotherapy or in combination with a sulfonylurea. Acarbose slows carbohydrate absorption after a meal, giving endogenous or injected insulin more time to respond to ingested gluc...

Abstract Applying the isoconversional method to data obtained from thermogravimetric analysis (TGA) can provide vital kinetic information. In this work, thermal decomposition and oxidation of antidiabetic drug glimepiride is analyzed in presence N 2 O . The study was done with without metal oxide catalysts explore their potential application solid wastewater upgrading. conducted using analysis....

Type 2 diabetes mellitus is characterised via way of means insulin resistance and innovative β mobileular Failure; therefore, secretagogues are beneficial for attaining enough glycemic control. Glimepiride a second-era sulfonylurea that stimulates pancreatic cells to launch Insulin. Additionally, has been proven paintings thru numerous more mechanisms. It Is administered as monotherapy in suffe...

Background: Although oral antidiabetic drugs have many beneficial pleiotropic effects, they are ‎not free from adverse reactions that may interfere with glucose homeostasis. This study aimed ‎to assess the effects of as add- on-therapy to metformin, on metabolic, ‎cardiac, and renal determinants. ‎ Material methods: A total number seventy-eight type 2 diabetes (T2D) patients who ‎were treated m...

Novel lipid nanoparticulates (NCs) were developed by a combined approach of precipitation and complexation with an aim to improve the solubility, stability and targeting efficiency of glimepiride (GLP). GLP NCs were prepared by precipitation process using PEG 20000 and further complexed with phospholipon90G (P90G). The NCs were evaluated for physicochemical characterization, such as drug lo...

For a female, type 2 diabetic patient, with 4 years duration of diabetes, Exenatide (Byetta) was prescribed as glycaemic control was not satisfactory along with Glimepiride and Metformin. She had gastrointestinal disturbances, since the first day of the injection. From the eighth day she developed signs of acute pancreatitis which was confirmed with CT-Scan and biochemical investigations. Byett...