Until recently, very little was known about the molecular mechanisms responsible for the development of glaucoma, a leading cause of blindness worldwide. Mutations in the glaucoma gene myocilin (MYOC, GLC1A) are associated with elevated intraocular pressure and the development of autosomal dominant juvenile glaucoma and a subset of adult-onset glaucoma. MYOC is expressed in the trabecular meshw...

PURPOSE To compare endoscopic cyclophotocoagulation (ECP) and the Ahmed drainage implant in the treatment of refractory glaucoma. METHODS Sixty-eight eyes of 68 patients with refractory glaucoma were prospectively assigned to either ECP or Ahmed tube shunt implantation. All procedures were performed by a single surgeon. Eyes that were included were pseudophakic with a history of at least one ...

TBE purpose of this communication is to record a series of cases of acute closed-angle glaucoma which appear to have resolved permanently without operation because of shortening of a segment of the iris. This shortening of a segment of the iris has been great enough, we believe, in these cases to eliminate relative "pupillary block" and therefore iris bombe; enough residual angle has then opene...

Glaucoma is a progressive optic neuropathy and medical therapy is the initial option for the treatment of this potentially blinding condition. Topical instillation of eye drops from the bottle is the most common glaucoma drug delivery form. Due to limited permeability of anterior ocular surface, natural clearance and drainage, eye drops contain large amounts of inactive ingredients. Effective p...

The balance between the secretion of aqueous humor by ciliary body and its drainage through 2 independent pathways, trabecular meshwork uveoscleral outflow pathway; this will determine intraocular pressure, which is considered determining factor for glaucoma. Glaucoma an entity great clinical importance, being second cause blindness worldwide. There are different explanations pathophysiology di...

PURPOSE Orbital cellulitis (OC) as a complication of implanted aqueous drainage devices (ADD) for glaucoma is an uncommon phenomenon. The authors report two cases of infectious OC in patients with a history of congenital glaucoma and placement of ADD. METHODS Clinical records of two patients with ADD who subsequently developed OC were reviewed for presenting symptoms, signs, medical and surgi...

OBJECTIVES To evaluate the analgesic effect as well as patient cooperation and satisfaction with sub-tenon's anesthesia in glaucoma surgery. MATERIAL AND METHODS Prospective uncontrolled study. Fifty-three patients who underwent glaucoma surgery, with or without cataract extraction, with sub-Tenon's anesthesia have been studied. Satisfaction and cooperation were evaluated on a qualitative sca...

To evaluate the efficacy of amniotic membrane in the management of painful bullous keratopathy secondary to the intractable glaucoma and in preventing exposure of drainage devices, we inserted Ahmed valve with amniotic membrane patch graft over the implant itself, and debrided corneal epithelium with amniotic membrane graft over the exposed stroma as a single operation. During the follow-up per...