OBJECTIVE The objective of this study was to review the treatment outcomes of patients with secondary glaucoma in cases of autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), a hereditary autoimmune uveitis due to mutations in CAPN5. PATIENTS AND METHODS A retrospective, observational case series was assembled from ADNIV patients with secondary glaucoma. The main outcome me...

The neurodegenerative disease glaucoma is one of the leading causes of blindness in the world. Glaucoma is characterized by progressive visual field loss caused by retinal ganglion cell (RGC) death. Both surgical glaucoma treatments and medications are available, however, they only halt glaucoma progression and are unable to reverse damage. Furthermore, many patients do not respond well to trea...

We have all heard many times that “Glaucoma is the second most common treatable cause of blindness worldwide”. Glaucoma is a significant public health concern, being the leading cause of irreversible blindness and consistently ranking among the leading causes of blindness in virtually every nation. In developing countries, cataract is the leading cause of blindness. In developed countries, the ...

IMPORTANCE Glaucoma can remain asymptomatic until a severe stage, resulting in a high prevalence of undiagnosed glaucoma worldwide. Asia accounts for 60% of the world's total glaucoma cases. To our knowledge, no epidemiological studies have assessed ethnic differences in undiagnosed glaucoma among various Asian subgroups. OBJECTIVE To determine the prevalence of, risk factors for, and visual ...

PURPOSE The purpose of the present study was to describe the prevalence, incidence and geographic variation of glaucoma in Denmark in the period from 1996 to 2011. Moreover, the aim was to identify the treatment patterns of glaucoma within the studied period. METHODS All Danish citizens were included throughout the study period. The National Prescription Registry was used to identify all clai...

Importance: Primary open angle glaucoma, an age-related, retinal neurodegenerative disease of unknown etiology, is treated by lowering intraocular pressure, even though elevated pressure present in only about 60% patients. Since we found that tolbutamide, which inhibits the opening ATP-sensitive potassium channels, modulates aqueous dynamics with a significant increase outflow, and since aquapo...

BACKGROUND The treatment for infantile glaucoma is surgical. Treatment options include goniotomy, trabeculotomy, combined trabeculotomy-trabeculectomy, and trabeculectomy. METHODS Patients who had a follow up of 5 years or longer after primary trabeculectomy were examined to determine the long term stability in infantile glaucoma. RESULTS In eyes with primary infantile glaucoma 92.3% achiev...

1. Abraham N, Yoseff G, Michael B, Yoram E. Biocompatibility of the Ex-PRESS® miniature glaucoma drainage implant. J Glaucoma. 2003;12:275–80. 2. Gallego-Pinazo R, López-Sánchez E, Marín-Montiel J. Resultados postquirúrgicos en la cirugía combinada de glaucoma. Comparación del implante Ex-PRESS® con la trabeculectomía. Arch Soc Esp Oftalmol. 2009;84: 293–8. 3. Francis BA, Singh K, Lin SC, Hodap...

1. Abstract 2. Introduction 2.1. Apoptosis 2.2. Caspases 2.2. Apoptosis and glaucoma 2.3. Caspase substrates in Alzheimer's disease 3. Methods 3.1. Chronic ocular hypertensive rat glaucoma model 3.2. Intraocular pressure (IOP) measurement and analysis 3.3. Optic nerve axon counts 3.4. Immunohistochemistry 3.5. Immunogold electron microscopy 3.6. ELISA 4. Rat model of chronic ocular hypertension...