Glycine and gamma-aminobutyric acid, type A (GABA(A)) receptors are members of the ligand-gated ion channel superfamily that mediate inhibitory synaptic transmission in the adult central nervous system. During development, the activation of these receptors leads to membrane depolarization. Ligands for the two receptors have important implications both in disease therapy and as pharmacological t...

Gingko biloba has cognitive benefits both in populations suffering from dementia and after acute treatment in healthy volunteers, with some evidence indicating that those with poorer cognitive performance show greater benefit. We have previously found that 1 week of treatment with ginkgo improved attention, memory and mental flexibility in post-menopausal women, but the evidence for any benefic...

BACKGROUND Dietary supplement use is common in older US adults; however, data on health risks and benefits are lacking for a number of supplements. OBJECTIVE We evaluated whether 10-y average intakes of 13 vitamin and mineral supplements and glucosamine, chondroitin, saw palmetto, Ginko biloba, garlic, fish-oil, and fiber supplements were associated with total mortality. DESIGN We conducted...

Extracts of Ginkgo biloba are widely used for the treatment of cognitive impairment. Whereas reviews have focused on the question whether ginkgo is effective to enhance cognition in general, little is known about specificity of improvement. This might be crucial for future trials, thus enabling hypotheses about sensitive outcome measures. Therefore, this article summarizes such information, i.e...

Bird's nest is widely used in Asia and good for consumers' health. The paper focused on optimizing beverage formulation that contain Salanganes'Nest harvesting at Yen Island, Nha Trang, Khanh Hoa province, Vietnam. input factors such as Nests essence, Ginkgo biloba, Chamomile, Glucosamine were studied. Target functions pH, viscosity, DPPH free radical scavenging activity. results showed the opt...

treatment strategies for ad will have to include a variety of interventions directed at multiple targets. so far, the outcomes with available approved medications for ad are often unsatisfactory, and there is a place for alternative medicine, in particular herbal medicine. herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary heal...

Abstract A reliable LC-MS/MS method for the determination of five bioactive constituents (bilobalide, BLL; ginkgolide A, GLA; B, GLB; C, GLC; rutin) Ginkgo biloba leaf extracts (GBE) in rat plasma was established, fully validated and applied to an intragastric pharmacokinetic study a preparation GBE rat. Samples were extracted with ethyl acetate. C18 column selected as analytical this method. M...