Crystallization and preliminary X-ray analysis of ginkbilobin-2 from Ginkgo biloba seeds: a novel antifungal protein with homology to the extracellular domain of plant cysteine-rich receptor-like kinases. Erratum A correction is made to one of the affiliations of the authors and also to a table heading in Miyakawa et al.

OBJECTIVES Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats...

Approximately 10 years ago, after publication of very poorly nvestigated case reports, a discussion began on a “hepatotoxic risk” ssociated with the ingestion of Cimicifuga preparations. After sevral years and thorough evaluations by numerous research groups nd responsible authorities (e.g. the HMPC) this risk was not subtantiated. A similar discussion has now been started following a publicaio...

AIM The present study investigates the effect of combined treatment with Ginkgo biloba and/or Rhodiola rosea on psychomotor vigilance task (PVT) and short-term working memory accuracy. SUBJECTS AND METHODS A total number of 112 volunteers were enrolled to study the effect of G. biloba and R. rosea on PVT and short-term working memory accuracy as compared to placebo effects, the central cognit...

Cytotoxic activity profiling of the n-hexane extract from fruit pulp Ginkgo biloba L. (Gingkgoaceae) led to purification 8 compounds. HPLC based identified a cytotoxic alkenylresorcinol. The was further separated by time-based fractionation in gradient condition, and cytotoxicity each fraction evaluated using 293, B16F10, BJAB, HCT116 cancer cells vitro. Bilobol isolated as an active constituen...

Dietary antioxidants are frequently proposed as protective agents for the vascular endothelium during the onset of atherosclerosis. This protection may occur at two distinct levels. First, they prevent oxidative modification of atherogenic lipoproteins (LDL). Second, they can provide a cellular protection against oxidized LDL-mediated endothelium dysfunction, although this mechanism remains poo...

OBJECTIVE To evaluate the efficacy of Ginkgo biloba as a complementary therapy for attention-deficit/hyperactivity disorder (ADHD). METHODS Children and adolescents with ADHD received methylphenidate (20-30 mg/day) plus either G. biloba (80-120 mg/day) or placebo for 6 weeks. Parent and teacher forms of the ADHD Rating Scale-IV (ADHD-RS-IV) were completed at baseline, week 2, and week 6. Trea...