Microbes exert a major impact on human health and disease by either promoting or disrupting homeostasis, in the latter instance leading to the development of infectious diseases. Such disparate outcomes are driven by the ever-evolving genetic diversity of microbes and the countervailing host responses that minimize their pathogenic impact. Host defense strategies that limit microbial pathogenic...

Kinetics of gray cast iron strengthening at room and elevated temperature (100°C, 182°C and 285°C) were studied using 100 specimens cast from one industrial heat of gray iron. Tensile strength and Brinell hardness was measured during age strengthening. Peak aging was observed at shorter times for higher temperatures and over-aging was observed at 182°C and 285°C. Statistically significant data ...

Recently, mutations causing juvenile hemochromatosis have been identified in a novel gene, hemojuvelin (HJV), located on chromosome 1. Mouse models of this disease have now been developed by 2 groups, Huang et al. and Niederkofler et al., through targeted disruption of the Hjv gene (see the related articles beginning on pages 2180 and 2187). These mutant mice will allow further investigation in...

The effects of language contact depend on many different factors, such as prestige, government and community support, people’s preference, linguistic proximity the languages, among other things. As such, while there are some broad potentially predictable outcomes in situations contact, it is important to analyze each situation its own context. aim this study examine maintenance social function ...

OBJECTIVE To examine intellectual and motor functioning of children who received micronutrient supplementation from 12 to 35 months of age. DESIGN Cohort follow-up of children 7 to 9 years of age who participated in a 2 × 2 factorial, placebo-controlled, randomized trial from October 2001 through January 2006. SETTING Rural Nepal. PARTICIPANTS A total of 734 children 12 to 35 months of ag...