The supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory neurons (MNC) which synthesize and release the peptide hormones vasopressin and oxytocin. Glutamate is a prominent excitatory neurotransmitter in the SON and regulates MNC excitability. NMDA receptors (NMDAR), a type of ionotropic glutamate receptor, mediate synaptic plasticity of MNCs and are necessary for c...

Subnuclear organization and spatiotemporal regulation of pre-mRNA processing factors is essential for the production of mature protein-coding mRNAs. We have discovered that a large protein called Son has a novel role in maintaining proper nuclear organization of pre-mRNA processing factors in nuclear speckles. The primary sequence of Son contains a concentrated region of multiple unique tandem ...

The present study tested the hypothesis that if polycystic ovary syndrome (PCOS) results from activating the noradrenergic outflow to the ovary, unilaterally sectioning the superior ovarian nerve (SON) will result in ovulation by the denervated ovary, and the restoration of progesterone (P4), testosterone (T) and estradiol (E2) normal serum level. A single 2 mg dose of estradiol valerate (EV) t...

I com mend the ex cel lent work of Dr Ken-nedy, Dr Lam, and the work ing group that pro vided the Clin i cal Guide lines for the Treat ment of De pres sive Dis or ders (1). This let ter is to pro vide up dated in for ma-tion from a sys tem atic re view of short-term dy namic psychotherapies (STDPs) cur rently be ing con ducted under the Cochrane Col lab o ra tion (2) and to dem on strate that c...

One of the landmarks in the history ofmodem biography is Edmund Gosse' s Father and son, first published anonymously in 1907. This book broke away from the tradition of eulogy and rhetoric in biography and gave a realistic portrayal of the complex relationship that existed between a father and son in mid-Victorian England. To the medical historian it is of interest because the third chapter des...