N E approach to the problem of how genes manifest themselves in develop0 ment has involved the analysis of the effects of changes at a given gene locus, such changes taking the form of alterations in the combination, dosage and position of alleles. Except where the analysis of modifier action is involved, the emphasis of this type of study is on the effects of a disturbance in the normal genoty...

BACKGROUND Growing evidence has linked HIV-1 resistance mutations and drug failure. The use of genotypic-resistance analysis to assist therapeutic decision-making in patients failing therapy has not been investigated. We assessed the virological and immunological impact of genotypic-resistance testing. METHODS We did a prospective, open, randomised, controlled study of HIV-1-infected patients...

BACKGROUND We sought to identify and characterize potential alterations in E2F-1, a transcription factor that binds to the retinoblastoma protein (pRB), in bladder neoplasms and to elucidate a possible role for E2F-1 as an oncogene or a tumor suppressor gene. METHODS Tumor samples from 133 evaluable patients with bladder cancer were analyzed for E2F-1 gene mutations by use of polymerase chain...

Elucidating the genomic diversity of CD209 gene promoter polymorphism could assist in clarifying disease pathophysiology as well as contribution to co-morbidities. CD209 gene promoter polymorphism has been shown to be associated with susceptibility to infection. We hypothesize that CD209 mutant variants occur at a higher frequency among Africans and in sickle cell disease. We analyzed the frequ...