For optical waveguides with high index-contrast and sharp corners, existing full-vectorial mode solvers including those based on boundary integral equations typically have only second or third order of accuracy. In this paper, a new full-vectorial waveguide mode solver is developed based on a new formulation of boundary integral equations and the so-called Neumann-to-Dirichlet operators for sub...

Imputation has enabled genomic selection in commercial livestock, taking advantage of a more cost effective Low Density (LD) panel, increasing the number of genotyped animals and hence accelerating the adoption process. A 5K LD panel has been employed commercially in New Zealand. This study investigated the accuracy of imputation to 50K and High Density (HD) panels using a new 15K panelbeing de...

Maximization of genetic gain in forest tree breeding programs is contingent on the accuracy of the predicted breeding values and precision of the estimated genetic parameters. We investigated the effect of the combined use of contemporary pedigree information and genomic relatedness estimates on the accuracy of predicted breeding values and precision of estimated genetic parameters, as well as ...

Citation: Spindel J, Begum H, Akdemir D, Virk P, Collard B, Redoña E, et al. (2015) Correction: Genomic Selection and Association Mapping in Rice (Oryza sativa): Effect of Trait Genetic Architecture, Training Population Composition, Marker Number and Statistical Model on Accuracy of Rice Genomic Selection in Elite, Tropical Rice Breeding Lines. PLoS Genet 11(6): e1005350. doi:10.1371/journal. p...

Modeling epistasis in genomic selection is impeded by a high computational load. The extended genomic best linear unbiased prediction (EG-BLUP) with an epistatic relationship matrix and the reproducing kernel Hilbert space regression (RKHS) are two attractive approaches that reduce the computational load. In this study, we proved the equivalence of EG-BLUP and genomic selection approaches, expl...

Over the past half century, thousands of quantitative trait loci (QTL) have been identified by using animal models and plant populations. However, the none-reliability and imprecision of the genomic regions of these loci have remained the major hurdle for the identification of the causal genes for the correspondent traits. We used a none-experimental strategy of strain number reduction for test...

In the clinical practice, many diseases such as glioblastoma, leukemia, diabetes, and prostates have multiple subtypes. Classifying subtypes accurately using genomic data will provide individualized treatments to target-specific disease subtypes. However, it is often difficult to obtain satisfactory classification accuracy using only one type of data, because the subtypes of a disease can exhib...

Reliable selection criteria are required for young riding horses to increase genetic gain by increasing accuracy of selection and decreasing generation intervals. In this study, selection strategies incorporating genomic breeding values (GEBVs) were evaluated. Relevant stages of selection in sport horse breeding programs were analyzed by applying selection index theory. Results in terms of accu...