Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Extensive genetic studies of the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene have revealed how variation in gene expression can be correlated with anxiety phenotypes. Complete genome-wide linkage s...

this study aimed to investigate the contribution of four common dfnb (“dfn” for deafness and “b” for autosomal resessive locus) loci and gjb2 gene mutations (exon 2) in hearing impairment in individuals living in markazi and qom provinces of iran. forty consanguineous iranian families with at least three affected individuals in family or pedigree who suffer from an autosomal recessive non-syndr...

accessory gene regulator (agr locus) is a global regulator of many virulence gene expressions instaphylococcus aureus. four interference classes related to genetic polymorphisms in the agr locus have sofar been described. in the present study, the agr locus specificity groups were studied within a total of 43 s.aureus isolates which were isolated from ewes with mastitis in three regions in the ...

parkinson’s disease (pd) is a prevalent neurodegenerative disease that usually affects individuals over 50 years of age. age at onset in a small subset of pd cases is considerably lower, and these are considered early-onset pd (eopd) patients. most pd cases appear sporadic, but approximately 15% are familial, and some of the familial cases exhibit mendelian inheritance. genetic analysis of fami...

Host genetic variants are known to confer resistance to Plasmodium blood stage infection and to control malaria severity both in humans and mice. This work describes the genetic mapping of a locus for resistance to liver stage parasite in the mouse. First, we show that decreased susceptibility to the liver stage of Plasmodium berghei in the BALB/c mouse strain is attributable to intra-hepatic f...

Long non-coding RNAs (lncRNAs) play key roles in the formation of nuclear bodies. In the fission yeast Schizosaccharomyces pombe, a lncRNA species termed meiRNA forms a nuclear dot structure at its own genetic locus, the sme2 locus, with its protein-binding partner Mei2. This dot structure, called Mei2 dot, promotes the progression of meiosis by suppressing Mmi1, a crucial factor involved in th...

In this study, genetic diversity of two different populations of Hamra goat breed of Morocco was investigated in 60 different samples (including 30 from Beni Arouss and 30 from Rommani) using fifteen microsatellite markers. A total of 145 alleles were detected with average number per locus of 8.67 and 8.07 in Beni Arouss and Rommani goats, respectively. The Shannon’s information index ranged fr...