This paper presents a genetic algorithm that evolves a fourpart musical composition–melodically, harmonically, and rhythmically. Unlike similar attempts in the literature, our composition evolves from a single musical chord without human intervention or initial musical material. The mutation rules and fitness evaluation are based on common rules from music theory. The genetic operators and indi...

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by modification or rearrangement of nucleosomes. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evident from every aspect of tumor biology including cell growth and differentiation, cell cycle cont...

Introduction: Multiple cerebral cavernous angiomas (CCA) have genetic origin. They are uncommon entity and rarely occurring with psychiatric manifestations. Case Presentation: A 28year-old man presented with delusional disorder some months after diagnosis of CCA for which a neurosurgical intervention had been performed. According to clinical and neuroimaging findings, we discuss the possible co...

Background Referral for genetic counseling and testing is appropriate for individuals whose families meet clinical criteria for Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and for some families with members that meet the Bethesda criteria. The FHPP is a prospective randomized trial to evaluate an intervention to promote colonoscopy in members of high risk CRC families. FHPP participants ...

a School of Psychology, University of Queensland, St. Lucia, Brisbane, Queensland, Australia b VU University, Department of Developmental Psychology and EMGO Institute for Health and Care Research, Amsterdam, the Netherlands c Department of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London d Institute of Psychology, Psychopathology and Clinical Intervention, Un...

Since the discovery of recombinant DNA techniques in the 1970s, the identification of diseaserelated genes has rested on epidemiologic data (1, 2). The implications of gene identification for research subjects, for the transition to clinical practice, for clinical practice itself, and, finally, for society at large form the basis of this review. The ethical issues inherent in genetic testing ha...

BACKGROUND The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the ABCB1 gene. Prior studies suggested that a common and functional genetic variant (C3435T, rs1045642) within ABCB1 influences clopidogrel treatment efficacy; however, existing data are highly inconsistent, because other studies failed to replicate this ...

The authors conducted a genome-wide linkage scan and positional association analysis to identify the genetic determinants of salt sensitivity of blood pressure (BP) in a large family-based, dietary-feeding study. The dietary intervention was conducted among 1,906 participants in rural China (2003-2005). A 7-day low-sodium intervention was followed by a 7-day high-sodium intervention. Salt sensi...

In a randomized controlled trial we tested the role of genetic differences in explaining variability in intervention effects on child externalizing behavior. One hundred fifty-seven families with 1- to 3-year-old children screened for their relatively high levels of externalizing behavior participated in a study implementing Video-feedback Intervention to promote Positive Parenting and Sensitiv...

Young women from hereditary breast and ovarian cancer (HBOC) families face a series of medical decisions regarding their cancer risk management and integrating this information into their life planning. This presents unique medical and psychosocial challenges that exist without comprehensive intervention. To help lay the groundwork for intervention, we conducted a qualitative study among young ...