Bacterial resistance to antibiotics is concern in healthcare-associated infections. On the other hand, bacterial tolerance to other antimicrobials, like heavy metals, has been neglected and underestimated in hospital pathogens. Silver has long been used as an antimicrobial agent and it seems to be an important indicator of heavy metal tolerance. To explore this perspective, we searched for the ...

background: the increasing pattern of multi-drug resistant (mdr) bacteria has limited therapeutic options especially for nosocomial isolates of klebsiella pneumoniae. therefore, the aim of this study was the molecular detection of 16s rrna methylase and blactx-m-15 among k. pneumoniae strains isolated from hospitalized patients in mofid, imam hossein and taleghani hospitals. materials and metho...

The aim of this study was to determine the prevalence of extended-spectrum b-lactamase (ESBL)producing Klebsiella pneumoniae isolated from urinary tract and bloodstream infections in a rural hospital in Manhiça, Mozambique. ESBLs were investigated among ceftriaxone-non-susceptible K. pneumoniae clinical isolates recovered between 2004 and 2009. Characterisation of blaCTX-M, blaSHV, blaOXA and b...

OBJECTIVES The spread of ESBL-producing Enterobacteriaceae among food animals/products has raised concerns about their possible transmission through the food chain. We aimed to characterize piggeries (pigs, piggery environments) as reservoirs of TEM-52- and CTX-M-encoding plasmids and clones. METHODS Forty-three samples from five Portuguese intensive production farms were studied (2006-07). T...

An outbreak of meningitis due to Citrobacter koseri in a special care baby unit is described. The organism showed a high capacity for spread among the babies on the unit and although the intestinal carriage rate was high, the clinical case:carrier ratio was low.

The presence of antibiotic resistance genes (ARGs) including those expressing ESBLs and AmpC-β-lactamases in Escherichia coli inhabiting the aquatic environments is a serious health problem. The situation is further complicated by the fact that ARGs can be easily transferred among bacterial species with the help of mobile genetic elements - plasmids, integrons, insertion sequences (IS), and tra...

CTX-M-15, recently detected in Portugal, is an extended-spectrum -lactamase (ESBL) that has spread worldwide (3, 4, 9, 10, 15). The basis for the successful dissemination of blaCTX-M-15 is unknown, although the spread of epidemic Escherichia coli strains and/or conjugative plasmids harboring blaCTX-M-15 has been documented (3, 6). We report the dissemination of blaCTX-M-15 associated with strai...

Introduction The high prevalence of urinary tract infections (UTIs) and rising resistance to beta-lactam antibiotics, which is a global therapeutic concern, are caused by Escherichia coli (E. coli) extended-spectrum beta-lactamases (ESBLs) producers. It unclear how E. that produces ESBLs spreads throughout Gezira state, Sudan. study aimed evaluate the dissemination class A D genes among recogni...

Background: ESBLs are enzymes which are capable of hydrolysing penicillins, broad-spectrum cephalosporins and monobactams. They are generally derived from TEM and SHV-type enzymes. Materials and methods: We investigated the presence of TEM, SHV, CTX-M, OXA and IBC beta-lactamase genes by PCR in 300 E. coli, 130 Klebsiella spp., 100 P. aeruginosa ve 23 Enterobacter spp. isolated from various cli...

The main objective of this study was to investigate the epidemiology, drug resistance and β-lactamase genotype distribution of enteropathogenic Escherichia coli (EPEC) isolated from pediatric patients with diarrhea in southern China. The prevalence of EPEC in children with diarrhea was 3.53%. The commonest serotypes were O55:K59 and O126:K71, and the typical EPEC were more prevalent than atypic...