aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its ...

Acetyl-coenzyme A carboxylase α (ACC-alpha) is considered as the key regulatory enzyme in fatty acid biosynthesis. ACC-alpha gene is located on Caprine chromosome 11 and is polymorphic in many goat breeds. In the current study, we aimed to find possible single nucleotide polymorphisms (SNPs) in the exon 1 region of the ACC-alpha gene in Iranian Mahabadi goat breed. Genomic DNA was extracted fro...

Background Varicocele is an abnormal dilation and tortuosity of veins of pampiniform plexus that drains the testis and causes an important change in semen.This abnormality is often one of the most common risk factors for male infertility. The aim of this study was to investigate the relationship between nitric oxide synthase 3 (NOS3) 4a4b (rs61722009) gene polymorphism, as a common genetic fact...

avian influenza is a contagious viral disease affecting the respiratory, digestive and nervous system of birds belong to orthomyxovirus family. in the chicken mx gene, type of amino acid at position 631 determines the antiviral activity against influenza and vesicular stomatitis virus. a single nucleotide polymorphism (snp) at position 2032, responsible for the variation of amino acid at positi...

background: an association between lung cancer and chemokines has been advocated in the recent years. this study aims at investigating the association between lung cancer and 16c/a single nucleotide polymorphism (snp) (rs. 4359426) in c-c motif chemokine 22 (ccl22) as well as c1014t snp (rs. 2228428) in c-c chemokine receptor type 4 (ccr4), which serves as the receptor for ccl22. methods: genot...

purpose: to investigate the effect of ccl2c-2512t polymorphism on age-related macular degeneration (amd). methods: this study enrolled 48 patients originating from northeast of iran who suffered from dry type amd. the association of c-2518t in the promoter region of ccl2 gene was investigated using polymerase chain reaction (pcr) and restriction fragment length polymorphism (rflp). control grou...

quantitative traits locus for milk production traits has been described on centromeric end of bovine chromosome 14. reports name the acyl coa: diacylglycerol acyltransferase (dgat1) gene as a potential candidate gene with dinucleotide substitution (aa to gc) in exon viii which causes the change of lysine to alanine in amino acid (k232a).the aim of the present study was to estimate the frequency...