The aim of the project was to identify biologically relevant novel gene clusters by using combined genomic data instead of using only gene expression data in isolation. The clustering algorithm based on self-organizing maps (Kasturi et al., 2005) was extended and implemented in order to use gene location data together with the gene expression and the motif occurrence data for gene clustering. A...

Genes involved and proteins TAL1 Location 1p32 DNA/RNA Complex alternate splicing. Protein Contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation. Yet unknown gene Location 5q31 Result of the chromosomal anomaly Hybrid gene Description Breakpoint on TAL1 was found 10 kb upstream the gene, as was found in the ...

Packaging of eukaryotic genomes into chromatin affects every process that occurs on DNA. The positioning of nucleosomes on underlying DNA plays a key role in the regulation of these processes, as the nucleosome occludes underlying DNA sequences. Here, we review the literature on mapping nucleosome positions in various organisms, and discuss how nucleosome positions are established, what effect ...

the aim of this study was to investigate the frequency, location and type of rpob gene mutations in mycobacterium tuberculosis (mtb) collected from patients in the southern endemic region of iran. drug susceptibility testing was determined by using the bactec system and the center for diseases control’s (cdc) standard conventional proportional method. in 29 rifampicin-resistant mtb (85%) isolat...

zucchini yellow mosaic virus (zymv) causes high yield losses to cucurbits in many parts of the world. during a survey in summer and fall of 2008 and 2009, 392 collected from different fields in khorasan razavi, northern khorasan and southern khorasan provinces were tested based on das-elisa tests using zymv specific polyclonal antibody. the result showed that 72 out of 392 samples were infected...

The existence of different domains within the nucleus has been clear from the time, in the late 1920s, that heterochromatin and euchromatin were discovered. The observation that heterochromatin is less transcribed than euchromatin suggested that microscopically identifiable structures might correspond to functionally different domains of the nucleus. Until 15 years ago, studies linking gene exp...