The lengthy course of IgA nephropathy and the possibility of good outcomes without therapy suggest nontoxic therapies such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs.) Among patients with IgA nephropathy, both ACE inhibitors and ARBs reduce the transglomerular passage of large, but not small, molecules, reducing proteinuria. The antiproteinuric eff...

The ability of human neutrophils to express a variety of genes encoding inflammatory mediators is well documented, and mounting evidence suggests that neutrophil-derived cytokines and chemokines contribute to the recruitment of discrete leukocyte populations at inflammatory sites. Despite this, our understanding of the signaling intermediates governing the generation of inflammatory cytokines b...

MicroRNAs (miRNAs) are key regulators of gene expression and modulators of diverse biological pathways. Analyses of miRNA function as well as therapeutic managing of miRNAs rely on cellular administration of miRNA inhibitors which may be achieved by the use of viral vehicles. This study explores the miRNA-suppressive capacity of inhibitors expressed intracellularly from lentivirus-derived gene ...

The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one the most frequently deregulated driver genes in human cancer. Because its high prevalence deregulation causal role cancer formation, maintenance progression, targeting theoretically an attractive strategy for treating As a potential anticancer target, was traditionally regarded as undruggable due to absence suitable pocke...

the organic deposition particularly asphaltenes has many detrimental effects on the oil industries, such as plugging in pipelines, wellbore and facilities and subsequently, considerable reduction in well productivity.asphaltenes are the most polar fractions, which they have been dispersed as colloidal clusters in crude oil. the accumulation of these clusters lead to the flocculation of colloids...

The evolutionary success of phytophagous insects depends on their ability to efficiently exploit plants as a source energy for survival. Herbivorous largely depend the efficiency, flexibility, and diversity digestive physiology sophistication detoxification system use chemically diverse host food sources. fall armyworm, Spodoptera frugiperda (J.E. Smith), is polyphagous pest many commercially i...

Expansion of the CGG.CCG-repeat tract in the 5' UTR of the FMR1 gene to >200 repeats leads to heterochromatinization of the promoter and gene silencing. This results in Fragile X syndrome (FXS), the most common heritable form of mental retardation. The mechanism of gene silencing is unknown. We report here that a Class III histone deacetylase, SIRT1, plays an important role in this silencing pr...