نتایج جستجو برای: gelatinases

تعداد نتایج: 2269  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2001
M S Pepper

Extracellular proteolysis is an absolute requirement for new blood vessel formation (angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and plasminogen activator (PA)-plasmin systems during angiogenesis. Specifically, a role for gelatinases (MMP-2, MMP-9), membrane-type 1 MMP (MMP-14), the urokinase-type PA receptor, and PA inhibitor 1 has been clearly defined in...

2009
Melba Muñoz Markus M. Heimesaat Kerstin Danker Daniela Struck Uwe Lohmann Rita Plickert Stefan Bereswill André Fischer Ildikò Rita Dunay Kerstin Wolk Christoph Loddenkemper Hans-Willi Krell Claude Libert Leif R. Lund Oliver Frey Christoph Hölscher Yoichiro Iwakura Nico Ghilardi Wenjun Ouyang Thomas Kamradt Robert Sabat Oliver Liesenfeld

Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We report interleukin (IL)-23-mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation in the ileum of infected mice. MMP-2 deficiency as well as therapeutic or prophylactic selective gelatinase blockage protect...

Journal: :Oncology reports 2014
Katarzyna Augoff Anita Hryniewicz-Jankowska Renata Tabola Leszek Czapla Piotr Szelachowski Jaroslaw Wierzbicki Krzysztof Grabowski Aleksander F Sikorski

To better understand the role of membrane-associated proteolytic systems in the development of esophageal cancer, we studied the expression of two serine proteases, fibroblast activation protein-α (FAP-α) and dipeptidyl peptidase IV (DPPIV) and three metalloproteinases, matrix metalloproteinase (MMP)-2, MMP-9 and MT1-MMP in 24 primary esophageal squamous cell carcinoma (ESCC) tissues and paired...

Journal: :Drug discoveries & therapeutics 2015
Munehiro Nakata Shota Kawaguchi Ayami Oikawa Akito Inamura Shunki Nomoto Hirokazu Miyai Tomomi Nonaka Saeko Ichimi Yoko Fujita-Yamaguchi Chuan Luo Bo Gao Wei Tang

An aqueous extract from toad skin, cinobufacini, has been known to possess anticancer ability. The present study examined effect of toad skin extract on activity of gelatinases including matrix metalloproteinases-2 and -9 which play an important role in invasion of carcinoma cells. Gelatinase activities derived from fetal serum albumin and culture medium of human breast carcinoma cell line MDA-...

2015
Steven R. Van Doren

Most abundant in the extracellular matrix are collagens, joined by elastin that confers elastic recoil to the lung, aorta, and skin. These fibrils are highly resistant to proteolysis but can succumb to a minority of the matrix metalloproteinases (MMPs). Considerable inroads to understanding how such MMPs move to the susceptible sites in collagen and then unwind the triple helix of collagen mono...

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 2006
Xueguang Zhang Xiangmei Chen Quan Hong Hongli Lin Hanyu Zhu Qingxin Liu Jianzhong Wang Yuansheng Xie Xiyao Shang Suozhu Shi Yang Lu Zhong Yin

Imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases (MMPs/TIMPs) takes part in age-related renal fibrosis; so does molecular inflammation. As several inflammatory mediators including intercellular adhesion molecule-1 (ICAM-1) are substrates of MMPs, we speculated that TIMP-1 might affect ICAM-1 through MMPs and subsequently promote age-related renal fibrosis. Then...

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