نتایج جستجو برای: gefs
تعداد نتایج: 744 فیلتر نتایج به سال:
Introduction The Center for International Meetings on Biology workshop on ‘Exchange Factors’ provided an up-to-date view of how guaninenucleotide-exchange factors (GEFs) affect the biochemical pathways that regulate the Ras superfamily of small GTPases, and how these molecules function as part of an interrelated network of regulatory proteins that mediate the biological responses of Ras-like GT...
The Rho family GTPases regulate many cellular functions including the organization, mechanics, and dynamics of the actin cytoskeleton. Re-engineering the highly conserved autoinhibitory structure of GEFs, Yeh et al. (2007) generated novel synthetic proteins that regulated Rho GTPase signaling and cell morphology, highlighting the power of protein module engineering.
The ADP-ribosylation factor 6 (ARF6) small GTPase functions as a GDP/GTP-regulated switch in the pathways that stimulate actin reorganization and membrane ruffling. The formation of active ARF6GTP is stimulated by guanine nucleotide exchange factors (GEFs) such as cytohesins, which translocate to the plasma membrane in agonist-stimulated cells by binding the lipid second messenger phosphatidyli...
PURPOSE Generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy in infancy (SMEI) are associated with sodium channel α-subunit type-1 gene (SCN1A) mutations. Febrile seizures and partial seizures occur in both GEFS+ and SMEI; sporadic onset and seizure aggravation by antiepileptic drugs (AEDs) are features of SMEI. We thus searched gene mutations in isolated cases ...
The Rac1 small GTPase is responsive to a large array of extracellular signals and in turn controls a wide variety of cellular functions—including actin dynamics. New findings add an additional layer of intricacy to the already complex process of regulating Rac1 activity, via a positive feedback loop involving the actin-binding protein coronin 1A, the Rac1 exchange factor ArhGEF7, the Rac1 effec...
Abstract The largest medium-range (72–120 h) cross-track errors (CTE) of tropical cyclone (TC) forecasts from the Global Ensemble Forecast System (GEFS) over northern Atlantic Ocean are examined for 2008–16 seasons. 38 unique within upper quartile most negative CTEs (i.e., left-of-track bias larger than 250 km by 72 do not have a clear common source steering error, although 12 involve underpred...
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