Bone lengthening with osteotomy and gradual distraction was achieved in 57 rats, and the effect of mechanical tension-stress on gene expression of bone morphogenetic proteins (BMPs) was investigated by in situ hybridization and Northern blot analysis using probes of BMP-2, BMP-4, BMP-6, BMP-7, and growth/differentiation factor (GDF)-5. There was a lag phase for 7 days after femoral osteotomy un...

Geological disposal is the globally preferred long-term solution for higher activity radioactive wastes (HAW) including intermediate level waste (ILW). In a cementitious system, cellulosic items present in ILW may undergo alkaline hydrolysis, producing significant quantities of isosaccharinic acid (ISA), chelating agent radionuclides. Although microbial degradation ISA has been demonstrated, it...

Abstract Since its discovery in 2009, the IBEX energetic neutral atom (ENA) Ribbon has been a subject of numerous studies. It appears at energies ∼0.5–6 keV and is most pronounced ∼1–3 keV. almost circular, ∼20°–40° wide, center lies near pristine local interstellar magnetic field direction, whose lines are draped around heliosphere. The intensity enhanced above more diffuse, globally distribut...

UNLABELLED Gastroduodenal refluxate found in the upper aerodigestive tract is not clinically uncommon. We recently demonstrated the neoplastic potential of gastroduodenal fluids (GDF) on hypopharyngeal mucosa, via NF-κB, using in vitro and in vivo models. Here we will explore the in vivo effect of GDF on laryngeal mucosa (LM) to induce early preneoplastic lesions related to NF-κB activation, al...

Technetium-99 is one of the most important isotopes likely to be disposed of in the proposed UK Geological Disposal Facility (GDF) for higher-activity radioactive wastes. This is due to its long half-life, high fission yield, and its ability to migrate through the geosphere when in its oxidised, pertechnetate form. However, much of the technetium in the GDF is likely to be in the lower oxidatio...

O objetivo geral deste artigo é fazer uma descrição de Constituintes Extraoracionais (ECCs) no português, adotando a posição Giomi e Keizer (2020) que esses constituintes, sinalizam determinadas funções retóricas na superfície textual, não podem ser deixados limbo por teoria voltada para o princípio adequação pragmática como Gramática Discursivo-Funcional (GDF). propósito específico estudo most...

Introduction: A pre-therapeutic distinction between benign and malignant thyroid nodules is critical for deciding the therapeutic strategy, wherein fine-needle aspiration cytology plays a major role. However, there are grey-zone categories in Bethesda system reporting cytopathology, which currently, universally accepted pattern FNAC. Several immunomarkers studied these ‘indeterminate’ lesions h...

Plasma levels of folates and thymidine in mice are about 10-fold higher than in humans and may influence the therapeutic efficacy of thymidylate synthase (TS) inhibitors, such as 5-fluorouracil (5FU) and the antifolates pemetrexed (MTA) and raltitrexed (RTX). Therefore, we tested their therapeutic efficacy in various murine tumor models, grown in mice on a normal and a folate-depleted diet, wit...

Plasma levels of folates and thymidine in mice are about 10-fold higher than in humans and may influence the therapeutic efficacy of thymidylate synthase (TS) inhibitors, such as 5-fluorouracil (5FU) and the antifolates pemetrexed (MTA) and raltitrexed (RTX). Therefore, we tested their therapeutic efficacy in various murine tumor models, grown in mice on a normal and a folate-depleted diet, wit...