نتایج جستجو برای: gd protein
تعداد نتایج: 1244233 فیلتر نتایج به سال:
OBJECTIVE Gadolinium neutron capture therapy (GdNCT) is a potential treatment for malignant tumors based on two steps: (1) injection of a tumor-specific (157)Gd compound; (2) tumor irradiation with thermal neutrons. The GdNC reaction can induce cell death provided that Gd is proximate to DNA. Here, we studied the nuclear uptake of Gd by glioblastoma (GBM) tumor cells after treatment with two Gd...
BACKGROUND Gaucher disease (GD) is a genetic disease caused by mutations in the GBA1 gene which result in reduced enzymatic activity of β-glucocerebrosidase (GCase). This study identified the progranulin (PGRN) gene (GRN) as another gene associated with GD. METHODS Serum levels of PGRN were measured from 115 GD patients and 99 healthy controls, whole GRN gene from 40 GD patients was sequenced...
The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(iii) complexes such as Gd-DOTA), without losing affinity for the target proteins. Here, we report robust synthetic procedures for the preparation of trivalent Gd-DOTA reagents with various chemical h...
خواص ساختاری, ترابردی و مغناطیسی نمونه های روتنوکوپرات ru(gd1.5-xprx) ce0.5sr2cu2o10-d با 0 ≤ x ≤0.1و rugd1.5(ce0.5-xprx) sr2cu2o10-d با0 ≤ x ≤ 0.2 که به روش واکنش حالت جامد ساخته شدند, با نمونه rugd1.5(gdxce0.5-x) sr2cu2o10-d با0 ≤ x ≤ 0.3 مقایسه گردید. طیف پراش اشعه x نمونه های مختلف به دست آمد و پارامترهای شبکه بر حسب مقادیر متفاوت آلایش pr توسط تحلیل ریتولد محاسبه شد. جهت بررسی خواص مغناطی...
The scintillation decay of cerium-doped gadolinium oxyorthosilicate Gd2(Si04)0:Ce is lengthened by the energy transfer from Gd to Ce. To investigate the role of the Gd in the scintillation processes, the Gd was partially replaced by optically inactive rare earth elements, Y and Lu, and the effective transfer rates from Gd to Ce were measured as a function of Gd and Ce concentrations using UVand...
Executive dysfunction (ED) in geriatric depression (GD) is common, predicts poor clinical outcomes and often persists despite remission of symptoms. Here we develop a neuroplasticity-based computerized cognitive remediation-geriatric depression treatment (nCCR-GD) to target ED in GD. Our assumption is that remediation of these deficits may modulate the underlying brain network abnormalities sha...
OBJECTIVE To examine the factors associated with the persistence of childhood gender dysphoria (GD), and to assess the feelings of GD, body image, and sexual orientation in adolescence. METHOD The sample consisted of 127 adolescents (79 boys, 48 girls), who were referred for GD in childhood (<12 years of age) and followed up in adolescence. We examined childhood differences among persisters a...
Membrane fusion induced by enveloped viruses proceeds through the actions of viral fusion proteins. Once activated, viral fusion proteins undergo large protein conformational changes to execute membrane fusion. Fusion is thought to proceed through a "hemifusion" intermediate in which the outer membrane leaflets of target and viral membranes mix (lipid mixing) prior to fusion pore formation, enl...
OBJECTIVE To investigate whether gallstone disease (GD) increases the risk of developing cardiovascular disease (CVD) in a large population-based cohort. METHODS A study population including 6,981 patients with GD was identified from The Taiwan National Health Insurance Research Database between 2004 and 2005. GD patients were defined as patients with principal discharge diagnoses of cholelit...
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