This question assumes that we would want to control a SIM, rather than granting it complete freedom. Science fiction abounds with stories in which a SIM pursues a plan that does not please its human creators. For example, Colossus (the inspiration for the movie The Forbin Project) presents a plausible scenario involving a SIM created to manage the nuclear weaponry of the USA [6]. In the end, th...

Towards a better representation of the solar cycle in general circulation models K. M. Nissen, K. Matthes, U. Langematz, and B. Mayer Institut für Meteorologie, Freie Universität Berlin, Carl-Heinrich-Becker-Weg 6–10, 12165 Berlin, Germany National Center for Atmospheric Research, 3450 Mitchell Lane, Boulder, CO 80301, USA Institut für Physik der Atmosphäre, Deutsches Zentrum für Luftund Raumfa...

The aim of this study is to evaluate the bioactive compounds in the ethanolic leaf extract of Azima tetracantha by using Gas chromatographyMass Spectrometry (GCMS). Azima tetracantha leaves were collected from Ariyalur District, Tamil Nadu. The dried leaf powder was extracted with the solvent ethanol by using Soxhlet apparatus. One microlitre of the extract was subjected for analysis by GCMS to...

Global climate models (GCMs) are important tools for addressing climate change questions at a global scale. Recent research has attempted to combine outputs from multiple GCMs to quantify uncertainty in regional climate change, which may ultimately inform regional stakeholders and policy-makers. Using a case study, we illustrate a potential path toward improvement in an existing Bayesian formul...

BACKGROUND In a previous study, we showed that simvastatin (SIM) therapy normalized sympathetic outflow and cardiovascular reflex regulation in chronic heart failure (CHF). However, the precise neural and cellular pathways for these effects are unknown. We hypothesized that SIM exerts its beneficial effect on autonomic function in CHF by downregulating central angiotensin II (Ang II) and supero...