Giant cell arteritis (GCA) is a granulomatous vasculitis affecting persons over 50 years of age. The inflammatory infiltrate, which is targeted at the aorta and its proximal branches, includes activated CD4+ helper T cells, histiocytes, and giant cells. To investigate whether the genetic polymorphism of the HLA-DRB1 genes contributes to the local accumulation of activated T cells, we have analy...

Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for demographics, cardiovascular risk factor, severe edentulism, symptoms of depression, the MoCA score,...

Giant cell arteritis (GCA) is the most common primary systemic vasculitis in western countries in individuals over the age of 50. It is typically characterised by the granulomatous involvement of large and medium sized blood vessels branching of the aorta with particular tendencies for involving the extracranial branches of the carotid artery. Generally the diagnosis is straightforward when cha...

UNLABELLED Giant cell arteritis (GCA) is a systemic vasculitis with symptoms that could cause a patient to present to a general dental practitioner. A case of GCA that presented as headache, jaw claudication, unilateral visual loss and tongue ulceration leading to necrosis is reported and the literature reviewed, with an emphasis on dentally relevant aspects. It is vital that GCA is not overloo...

Giant cell (temporal) arteritis (GCA) is a granulomatous inflammatory disease affecting particularly large and medium sized arteries. Most cases occurred in the Scandinavian elderly greater than 50-year-old. The American Africans and the oriental have a much lower incidence of GCA. Headache, fever and anemia are common symptoms. Blindness is the most dreaded complication. Reported cases of defi...

Sir, The association between giant cell (temporal) arteritis (GCA) and other autoimmune diseases such as autoimmune thyroiditis (15), primary biliary cirrhosis (6), Sjögren syndrome (7), systemic lupus erythematosus (1, 8) and progressive systemic sclerosis (9) has occasionally been reported. Although the association of GCA with most of these disorders is essentially anecdotal, it provides addi...

GCA is the commonest of all the vasculitides. Visual loss occurs in up to one-fifth of patients, which may be preventable by prompt recognition and treatment [1,2]. The aim of these guidelines is to encourage the prompt diagnosis and management of GCA, with emphasis on the prevention of visual loss. Their scope is to provide evidence-based advice for the assessment and diagnosis of GCA, for ini...

SUMMARY This letter proposes a novel geographic channel assignment (GCA) framework for dynamic channel allocation (DCA) in broad-band wireless access networks (BWANs). The proposed GCA scheme is based on the characteristics of radio propagation, which focuses on the relationship between transmission distances and communication parameters, e.g., signal-to-noise ratio (SNR) etc., and uses a signa...

Giant cell arteritis (GCA) is a systemic vasculitis of medium and large vessels. Corticotherapy is the cornerstone treatment, but most patients fail to reach remission or relapse during the weaning of Glucocorticoids (GC). Here we report 2 patients with corticoid dependent GCA, successfully treated with Tocilizumab (TCZ), with a rapid clinical and biological outcome allowing the tapering of GC,...

Giant cell arteritis (GCA) is the most common vasculitis in Western countries in individuals over the age of 50. The diagnosis is relatively straightforward when typical features, such as headache, jaw claudication or other ischemic complications are present. Although atypical presentations of GCA have been described, herein we report for first time low back pain as the presenting manifestation...