Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract with immunohistochemical reactivity for CD117 antibody. Gastrointestinal stromal tumor with synchronous gastric cancer is rare. A 69-year-old male presented with one-week history of epigastrium pain and vomit was admitted to our hospital. Subtotal gastrectomy and D2 lymph node dissection were performed,...

Octamer-binding transcription factor 4 (OCT-4) is an important marker of cellular de-differentiation that can be induced by environmental stressors, such as acidity. Here we demonstrate that chronic acidic stress in solid tumors induced OCT-4 expression in fibroblasts and other stromal cells in four tumor models. The results have implications for how tumors utilize pH modulation to recruit asso...

Received October 2009 Accepted November 2009 INTRODUCTION A gastrointestinal stromal tumor (GIST) is primarily located in the gastrointestinal tract. It is classified as a mesenchymal tumor that shows a CD117 (c-KIT)-positive mesenchymal spindle or epithelioid neoplasm. Tumors outside the gastrointestinal tract that were histologically similar to GISTs and showed immunopositivity for CD117 were...