The present study developed an oral hepatocyte growth factor (HGF) gene therapy strategy for gastric ulcers treatment. An attenuated Salmonella typhimurium that stably expressed high HGF (named as TPH) was constructed, and the antiulcerogenic effect of TPH was evaluated in a rat model of gastric ulcers that created by acetic acid subserosal injection. From day 5 after injection, TPH (1 × 10⁹ cf...

One hundred and forty six gastric ulcer patients were given open treatment using 1 g cimetidine daily to heal their ulcers. Of 130 who completed the acute treatment period of eight weeks, 112 (86%) had healed ulcers. Of these 112 patients with healed ulcers, 108 entered a one year double blind study to compare the effect of cimetidine maintenance therapy (400 mg at night) with placebo. Of the 8...

Gastric ulceration is a prevalent condition of racehorses. A number of models of gastric ulceration have been described, but none mimic the conditions of a horse in training. The objectives of this study were to determine whether gastric ulcers could be induced and maintained in a group of horses in simulated race training. In addition, serum cortisol was measured on a weekly basis to investiga...

Pharmacognosy Research,2022,14,4,492-498.DOI:10.5530/pres.14.4.71Published:October 2022Type:Original ArticleAuthors:Adaobi C. Ezike, Nwoyi N. Bassey, Emenike Amah, Daniel U. Nwankpa, Aniebiet E. Samuel, and John O. Medewase Author(s) affiliations:Adaobi Ezike*, Department of Pharmacology Toxicology, Faculty Pharmaceutical Sciences, University Nigeria, Nsukka, Enugu, NIGERIA. Abstract:Background...

The changes caused by Helicobacter pylori are a slow, progressing inflammatory process developing from several to dozen years. H. pylori infection leads to an inflammatory response in the gastric mucosa with granulocyte infiltrates in an acute form of the inflammation, and lymphocytes, plasmatic, macrophages and eosinophils in a chronic form inducing the development of gastric and duodenal ulce...

Background & Aims: Short-term follow-up studies show matically reduces ulcer relapse rates. The few studies lower relapse rates of duodenal and gastric ulcers after in patients with gastric ulcers had similar findings. successful Helicobacter pylori eradication. The aim of Only a few studies have followed up on patients with this study was to determine the long-term outcome duodenal ulcers for ...

Every equine practitioner appreciates the delicate nature of the equine gut. Problems related to the small intestine and large intestine are well understood and routinely treated. What may be surprising to many is how often the stomach is affected. Specifically, the incidence of gastric ulcers is extremely high, particularly in performance horses. This article will review why horses suffer from...