Recently, modularity has emerged as a general attribute of complex biological systems. This is probably because modular systems lend themselves readily to optimization via random mutation followed by natural selection. Although they are not traditionally considered to evolve by this process, biological ligands are also modular, being composed of recurring chemical fragments, and moreover they e...

C o m m e n t a r y Stargazin (STZ), the prototypical member of the trans­ membrane AMPA receptor regulatory protein (TARP) family, can boost AMPA receptor activity to enhance synaptic currents as much as one third. The effects of STZ on microscopic and macroscopic AMPA receptor currents are consistent with a mechanism in which STZ facilitates opening of the AMPA receptor channel. How­ ever, th...

Most of the common foams are a two-phase medium of gas and liquid with a particular structure consisting of gas pockets trapped in a network of thin liquid lms and plateau borders. Some well known foams are bubble baths, dishwater detergents and the foam head on beers. Many oils foam when trapped gas is suddenly released under conditions of an abrupt drop in pressure. In some re ners in which t...

This is the second paper in a two-part series examining numerical simulations of buoyancy-driven flow in the presence of large viscosity contrasts. In the first paper, we demonstrated that a combination of three numerical tools, an extended ghostfluid-type method, the level set approach, and the extension velocity technique accurately simulate complex interface dynamics in the presence of large...

The sensitivity of H. Pylori to antibiotic treatment is well known. Politherapy (omeprazole or pantoprazole or ranitidine, amoxicillin and/or azithromycin and/or clarithromycin, metronidazole and bismuth citrate) notably changed the percentage of H. pylori eradication but rarely resolutive. Periodontal pockets treatment with topic metronidazole, calcium sulphate and potassium sulphate resulted ...

Recent nucleosynthesis calculations of Type II supernovae using advanced neutrino transport determine that the early neutrino winds are proton-rich. However, a fraction of the ejecta emitted at the same time is composed of neutron-rich pockets. In this paper we calculate the nucleosynthesis contribution from the neutron-rich pockets in the hot convective bubbles of a core-collapse supernova and...