نتایج جستجو برای: gamma coronavirus
تعداد نتایج: 163120 فیلتر نتایج به سال:
The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.
Coronavirus is a common cause of upper respiratory tract infection in children and has also been occasionally associated with lower respiratory tract infections. Use of reverse transcriptase polymerase chain reaction has aided in the rapid and reliable detection of these viruses, and thus has led to identification of these viruses as etiology of respiratory disease in more cases. We here presen...
شهرهایی که در دامنه های کوهستانی شکل گرفته اند به شدت تحت تاثیر محیط فعال پیرامون خود قرار گرفته و به وسیله مخاطرات ژیومورفولوژیکی موجود در آن مورد تهدید قرار می گیرند. شهر جوانرود به دلیل قرارگیری در پاپکوهای زاگرس چین خورده و نیز به دلیل گذر روخانه فصلی و دایمی سوریر در شرق و لیله در جنوب شهر دارای مخاطرات محیطی مختلف از جمله حرکات دامنه ای و سیل و طغیان رودخانه می باشد. در تحقق حاضر به منظور...
Effective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs. We conducted a cohort study examining multiple parameters of immune responses to SARS-CoV infection, aiming to identify the immune correlates of protection. We used a matrix of overlapping pep...
Coronaviruses are important pathogens that cause acute respiratory diseases in humans. Replication of the approximately 30-kb positive-strand RNA genome of coronaviruses and discontinuous synthesis of an extensive set of subgenome-length RNAs (transcription) are mediated by the replicase-transcriptase, a barely characterized protein complex that comprises several cellular proteins and up to 16 ...
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3C-like protease (3CL(pro) or M(pro)) is an attractive target for the development of anti-SARS drugs because of its crucial role in the viral life cycle. In this study, a compound database was screened by the structure-based virtual screening approach to identify initial hits as inhibitors of SARS-CoV 3CL(pro). Out of the 5...
Antigenic group 2 coronavirus was detected in a fecal sample of an adult alpaca by reverse transcription-PCR. The presence of alpaca coronavirus (ApCoV) in the small intestine was demonstrated by immune histochemistry with an antinucleocapsid monoclonal antibody that reacts with group 2 coronaviruses. Other common causes of diarrhea in adult camelids were not detected. We conclude that nutritio...
N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides via two steps. Bioactivity assay results (in vitro tests) demonstrated that some of these compounds are potent and selective inhibitors against SARS coronavirus 3CL protease with IC50 values ranging from 0.95 to 17.50 microM. Additionally, isatin 4o exhibited more potent inhibition for SARS coronavir...
A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant hu...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید