The cold-sensitive peach fruits are prone to chilling injury (CI). ?-aminobutyric acid (GABA) has been confirmed effectively improve peaches’ cold tolerance. This research aimed probe the role of dynamic changes in membrane lipid metabolism GABA-mediated tolerance and reveal underlying mechanisms based on metabolomics. GABA treatment improved by reducing phosphatidic (PA) accumulation via inhib...

GABA (gamma-aminobutyric acid) mediates cell-to-cell communication in eukaryotes and interspecies communication in host-microbe interactions. Agrobacterium tumefaciens induces the development of plant tumor in which GABA accumulates. Two periplasmic binding proteins Atu2422 and Atu4243 and their appropriate ABC-transporter are involved in the binding and importation of GABA. The structure of th...

The most abundant synapses in the central nervous system of vertebrates are inhibitory synapses that use the neurotransmitter gamma-aminobutyric acid (GABA). GABA is also an important neurotransmitter in C. elegans; however, in contrast to vertebrates where GABA acts at synapses of the central nervous system, in nematodes GABA acts primarily at neuromuscular synapses. Specifically, GABA acts to...

In our present work, some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their ?-aminobutyric acid-aminotransferase (GABA-AT) inhibition in-vivo anticonvulsant activity. Among all the synthesized derivatives, compound 7f was observed as most potent competitive inhibitor of GABA-AT (IC50 = 46.29 ± 3.19 µM, Ki 0.106 0.004 ?M). The acti...