نتایج جستجو برای: galectin 1

تعداد نتایج: 2755360  

2011
Peter Gál Tomáš Vasilenko Martina Kostelníková Ján Jakubco Ivan Kovác František Sabol Sabine André Herbert Kaltner Hans-Joachim Gabius Karel Smetana

Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform a histochemical study of their occurrence during wound healing using rat skin as an in vivo model. Wound healing is a dynamic process that exhibits three basic phases: inflammation, proliferation, and maturation. In this study antibodies against ker...

Journal: :Acta dermato-venereologica 2013
Sung Bin Cho Jun-Sub Kim Zhenlong Zheng Min Ju Choi Ihn Geun Choi Hong Shik Oh Keun Jae Ahn

Hypertrophic scars (HS) result from an imbalance between collagen biosynthesis and matrix degradation during wound healing. In this study a proteomics approach was used to compare the protein profiles of skin tissue obtained from patients with HS and healthy controls. One of the epidermal proteins, galectin-7 was markedly down-regulated in HS. Serum levels of galectin-7 in 27 patients with HS w...

Journal: :Glycobiology 2006
Gabriel A Rabinovich Albana Cumashi Germán A Bianco Domenico Ciavardelli Ida Iurisci Maurizia D'Egidio Enza Piccolo Nicola Tinari Nikolay Nifantiev Stefano Iacobelli

Galectins, a family of structurally related carbohydrate-binding proteins, contribute to different events associated with cancer biology, including apoptosis, homotypic cell aggregation, angiogenesis and tumor-immune escape. To interfere with galectin-carbohydrate interactions during tumor progression, a current challenge is the design of specific galectin inhibitors for therapeutic purposes. H...

Journal: :Anticancer research 2009
Stéphanie Cludts Christine Decaestecker Virginie Mahillon Dominique Chevalier Herbert Kaltner Sabine André Myriam Remmelink Xavier Leroy Hans-Joachim Gabius Sven Saussez

AIM To define specific staining patterns for the adhesion/growth-regulatory lectin tandem-repeat-type galectin-8 in hypopharyngeal and laryngeal tumor progression and relate these parameters to galectins 1, 3 and 7 in the quest to explore the galectin network. MATERIALS AND METHODS The level of expression of galectin-8 was determined immunohistochemically in a series of 18 and 16 cases of tum...

2013
Yung-Kuo Lee Tsung-Hsien Lin Chuan-Fa Chang Yu-Li Lo

Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves the upregulation of ATP binding cassette (ABC) transporters and induction of galectin-3 signaling. Galectin-3 plays an anti-apoptotic role in many cancer cells and regulates various pathways to activate MDR. Thus, the inhibition of galectin-3 has the potential to enhance the effic...

Journal: :Molecular human reproduction 2005
M von Wolff X Wang H-J Gabius T Strowitzki

The emerging functionality of the sugar code via cell surface glycans and endogenous lectins ascribes pertinent roles in cell physiology to the carbohydrate signals of cellular glycoconjugates. To initiate monitoring of endogenous lectins in human endometrium, we focused on a family of growth/adhesion-regulatory lectins, i.e. galectins. Comprehensive fingerprinting was performed on samples thro...

Journal: :Journal of immunology 2004
Andreas Sturm Martin Lensch Sabine André Herbert Kaltner Bertram Wiedenmann Stefan Rosewicz Axel U Dignass Hans-Joachim Gabius

Galectin-2 is structurally closely related to galectin-1, but has a distinct expression profile primarily confined to the gastrointestinal tract. Prominent differences in the proximal promoter regions between galectins-2 and -1 concern Sp1-, hepatocyte NF-3, and T cell-specific factor-1 binding sites. Of note, these sequence elements are positioned equally in the respective regions for human an...

2006
Marina I. Garín Chung-Ching Chu Dela Golshayan Eva Cernuda-Morollón Robin Wait Robert I. Lechler Robert Lechler

The naturally occurring population of dedicated regulatory T cells that co-express CD4 and CD25 is known to play a key role in the maintenance of peripheral T cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of β-galactoside-binding proteins, galectin-1, is over-expressed in regulatory T cells, and that expression is increased a...

Journal: :Journal of immunology 2013
Pampa Bhaumik Guillaume St-Pierre Valérie Milot Christian St-Pierre Sachiko Sato

When infection occurs, neutrophils rapidly migrate to the affected site. Although the neutrophils neutralize microorganisms, they can also cause tissue damage or render invasion pathways to pathogens. Thus, the migration could be either beneficial or unfavorable in the initial control of infection. Studies on neutrophil recruitment revealed its complexity, especially in terms of the regulation ...

2016
Kevin C. Haudek Patricia G. Voss John L. Wang Ronald J. Patterson

In previous studies, we reported that fractionation of HeLa cell nuclear extracts on glycerol gradients revealed an endogenous ∼10S particle that contained galectin-3 and U1 snRNP and this particle was sufficient to load the galectin polypeptide onto a pre-mRNA substrate. We now document that this interaction between the galectin-3-U1 snRNP particle and the pre-mRNA results in a productive spli...

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