نتایج جستجو برای: galectin

تعداد نتایج: 4550  

2014
Christoph-A von Klot Mario W Kramer Inga Peters Joerg Hennenlotter Mahmoud Abbas Ralph Scherer Thomas RW Herrmann Arnulf Stenzl Markus A Kuczyk Juergen Serth Axel S Merseburger

BACKGROUND Galectins are known to regulate cell differentiation and growth as well as cell adhesion and apoptosis. Galectins have been discussed as possible prognosticators for survival in renal cell cancer (RCC) and other urological tumors. They might also play an emerging role as possible new marker-proteins for RCC. In this study, we analyzed the expression of galectin-1 and galectin-3 mRNA ...

2012
Kyung-Hee Kim Yong-Kyun Kwon Chong-Kwan Cho Yeon-Weol Lee So-Hyun Lee Sang-Geun Jang Byong-Chul Yoo Hwa-Seong Yoo

OBJECTIVES Many efforts have shown multi-oncologic roles of galectin-3 for cell proliferation, angiogenesis, and apoptosis. However, the mechanisms by which galectin-3 is involved in cell proliferation are not yet fully understood, especially in human colon cancer cells. METHODS To cluster genes showing positively or negatively correlated expression with galectin-3, we employed human colon ca...

2017
Laura Díaz-Alvarez Enrique Ortega

Galectins are a group of evolutionarily conserved proteins with the ability to bind β-galactosides through characteristic carbohydrate-recognition domains (CRD). Galectin-3 is structurally unique among all galectins as it contains a C-terminal CRD linked to an N-terminal protein-binding domain, being the only chimeric galectin. Galectin-3 participates in many functions, both intra- and extracel...

2011
Rudolf A de Boer Dirk J A Lok Tiny Jaarsma Peter van der Meer Adriaan A Voors Hans L Hillege Dirk J van Veldhuisen

AIMS galectin-3 is an emerging biomarker which has been studied in relatively small heart failure (HF) cohorts with predominantly systolic HF. We studied the prognostic value of base-line galectin-3 in a large HF cohort, with preserved and reduced left ventricular ejection fraction (LVEF), and compared this to other biomarkers. METHODS we studied 592 HF patients who had been hospitalized for ...

Journal: :Clinica chimica acta; international journal of clinical chemistry 2016
A Rogier van der Velde Chris P H Lexis Wouter C Meijers Iwan C van der Horst Erik Lipsic Martin M Dokter Dirk J van Veldhuisen Pim van der Harst Rudolf A de Boer

BACKGROUND Fibrosis is a pivotal event in infarct repair and progressive remodeling after myocardial infarction (MI). Biomarkers may be used to monitor fibrosis, and therefore we evaluated the predictive value of galectin-3 and sST2 for cardiac remodeling after MI. METHODS Plasma galectin-3 and sST2 were measured in patients admitted with primary percutaneous coronary intervention (PCI) for a...

2014
Zhixiong Cai Yongyi Zeng Bo Xu Yunzhen Gao Sen Wang Jinhua Zeng Lihong Chen Aimin Huang Xiaolong Liu Jingfeng Liu

Galectin-4 is a multifunctional lectin found at both intracellular and extracellular sites. It could serve as a tumor suppressor intracellularly and promote tumor metastases extracellularly during colorectal cancer development. However, galectin-4 expression and its prognostic value for patients with hepatocellular carcinoma (HCC) have not been well investigated. Here we report that galectin-4 ...

2017
Carla Iacobini Claudia Blasetti Fantauzzi Giuseppe Pugliese Stefano Menini

Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate cartilage, where it favors chondrocyte survival and cartilage matrix mineralization. It was also shown to be highly expressed in differentiating osteo...

Journal: :The Journal of biological chemistry 2009
Pablo Argüeso Ana Guzman-Aranguez Flavio Mantelli Zhiyi Cao Jessica Ricciuto Noorjahan Panjwani

Maintenance of an intact mucosal barrier is critical to preventing damage to and infection of wet-surfaced epithelia. The mechanism of defense has been the subject of much investigation, and there is evidence now implicating O-glycosylated mucins on the epithelial cell surface. Here we investigate a new role for the carbohydrate-binding protein galectin-3 in stabilizing mucosal barriers through...

Journal: :International journal of molecular sciences 2016
Szu-Chia Chen Po-Lin Kuo

Galectin-3 is a 32- to 35-kDa member of the galectin family of b-galactoside-binding lectins, which is characterized by a carbohydrate recognition domain. Through its carbohydrate-binding function, it regulates cell growth, differentiation, and inflammation. It also plays a complex, context-dependent role in the kidneys. During development, it promotes nephrogenesis and is strongly expressed in...

2014
OSAMU SUZUKI MASAFUMI ABE

Galectin-1 is known to be one of the extracellular matrix proteins. To elucidate the biological roles of galectin-1 in cell adhesion and invasion of human anaplastic large cell lymphoma, we performed cell adhesion and invasion assays using the anaplastic large cell lymphoma cell line H-ALCL, which was previously established in our laboratory. From the cell surface lectin array, treatment with n...

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