BACKGROUND A minimum 4-point change at 6 months on the Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog) is deemed clinically important, but this cut-point has been little studied in relation to clinical meaningfulness. In an investigator-initiated, clinical trial of galantamine, we investigated the extent to which a 4-point change classifies goal attainment by individual patie...

Combination therapy with galantamine and memantine improves Behavioral and Psychological Symptoms of Dementia (BPSD) in patients with early-onset Alzheimer’s disease Atsushi Hamuro 天久台病院 精神科[〒 900-0005 沖縄県那覇市天久 1123] Amekudai Hospital, Department of Psychiatry (1123 Ameku, Naha, Okinawa 900-0005, Japan) (池嶋,朝田,2010).EOADと 65歳を超えて発症 する老年期のアルツハイマー型認知症は,病理所見 で老人斑と神経原線維を主に有するという点で同じ であるが,臨床症状,遺伝背景の...

The cholinesterase inhibitors donepezil, rivastigmine and galantamine have a modest and transient benefit in Alzheimer's disease. Their known adverse effects include bradycardia. A Canadian case-control study conducted between 2003 and 2008 showed a statistically significant increase in the risk of hospitalisation for bradycardia among patients who had been taking a cholinesterase inhibitor for...

Many secondary plant compounds are synthesized in response to stressed growing conditions. We tested the feasibility of exploiting this feature in a novel strategy for the commercial production of the plant alkaloid galanthamine. Experimental lines of Narcissus pseudonarcissus were established under marginal upland permanent pasture at four different sites. Over 80% of bulbs successfully establ...

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Methods: 131 patients with AD (mild, moderate degree) were included in the investigation according to the diagnostic criteria of DSM IV and MKB 10. 45 AD patients were on galantamine, 43-memantin and 43-combined therapy. The control group includes 45 patients. In our investigation in the main group of AD patients the duration of the disease was from 6 months to 4.3 years, on average 3.3 years. ...

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with characteristic clinical and pathologic features. Although multiple neural systems are affected, a key component of the degenerative process is a loss of cholinergic neurons and a subsequent reduction in nicotinic acetylcholine receptors (nAChRs), which are widely distributed and influence the release of multiple neurotran...