There is a recent trend of using lactic acid bacteria for the production gamma-aminobutyric (GABA). This study described method that combines fermentation and self-buffered whole-cell catalysis efficient GABA Levilactobacillus brevis CD0817. Upon completion fermentation, cells were recovered to conduct by which substrate L-glutamic was catalytically decarboxylated GABA. itself maintained acidit...

Herbal cosmetics are gaining popularity over chemicals for beauty products. However, natural products often prone to deterioration. Therefore, stability and compatibility testing the main examinations of safety reliability herbal cosmetics. Liquid crystal structures provide better application performances than conventional emulsion systems in terms stability, controlled release, moisturizing. R...

A large amount of gamma-aminobutyric acid (GABA) was found to accumulate in tomato (Solanum lycopersicum) fruits before the breaker stage. Shortly thereafter, GABA was rapidly catabolized after the breaker stage. We screened the GABA-rich tomato cultivar 'DG03-9' which did not show rapid GABA catabolism after the breaker stage. Although GABA hyperaccumulation and rapid catabolism in fruits is w...

GABA(B) receptor subtypes are based on the subunit isoforms GABA(B1a) and GABA(B1b), which associate with GABA(B2) subunits to form pharmacologically indistinguishable GABA(B(1a,2)) and GABA(B(1b,2)) receptors. Studies with mice selectively expressing GABA(B1a) or GABA(B1b) subunits revealed that GABA(B(1a,2)) receptors are more abundant than GABA(B(1b,2)) receptors at glutamatergic terminals. ...

GABA(B) receptors are G-protein-coupled receptors that mediate slow synaptic inhibition in the brain and spinal cord. These receptors are heterodimers assembled from GABA(B1) and GABA(B2) subunits, neither of which is capable of producing functional GABA(B) receptors on homomeric expression. GABA(B1,) although able to bind GABA, is retained within the endoplasmic reticulum (ER) when expressed a...

BackgroundThe latest diagnostic criteria for multiple sclerosis (MS) have revitalized the role of oligoclonal bands synthesis in cerebrospinal fluid (CSF-OCB). This study identifies predictors CSF-OCB-positivity among vivo metabolic markers subcortical gray/white matter MS patients after their first episode (CIS) and with relapsing-remitting course (RRMS).MethodsThe enrolled 13 CIS 23 RRMS pati...

background: the present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and gaba at dentate gyrus of streptozotocin-induced diabetic rats. methods: after 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and gaba were investigated. results: the results showed that glutamate levels were significantly decreased in dia...

Inhibition is crucial for normal function in the nervous system. In the CNS, inhibition is mediated primarily by the amino acid GABA via activation of two ionotropic GABA receptors, GABA(A) and GABA(C). GABA(A) receptor composition and function have been well characterized, whereas much less is known about native GABA(C) receptors. Differences in molecular composition, anatomical distributions,...

The present work was performed to show the possible interaction of GAB A, and GABAB receptors in catalepsy. The following results were obtained: 1- Muscimol (MUS), a GABAA agonist, induced catalepsy. This effect was dose-dependent. Baclofen (BAC), a GABAB agonist, had no effect in this respect. 2- Catalepsy induced by muscimol was potentiated by pretreatment of animals with bicuculline (BI...