Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the viral Envelope (Env). However, the generation of neutralizing Abs (NAbs) targeting these regions through vaccination has proven to be difficult. One conserved region of particular interest is the membrane proximal external region (MPER) ...

By JAMES C. WHITE A RARE FAMILIAL DISORDER characterized cytologically by enormous particles in all varieties of leukocytes has been reported from various parts of the world and is known in this country as the Chediak-Higashi (C.H.) syndrome.1-4 The variable clinical manifestations of patients with this disease have included defective pigmentation, neuropathies, lymphadenopathy, hepatosplenomeg...

Detailed experimental characterization of a laser‐clad metal matrix composite (MMC) consisting hard tungsten carbide particles embedded in comparatively soft nickel‐based is provided. Special focus the investigations placed on relationship between microstructure as‐deposited reinforcing and their hardness. Therefore, thermally induced dissolution carbides caused by laser deposition (LMD) proces...

hypothesis may still lbe a topic for controversy among philosophers, but among the great majority of active scientists I think it is accepted without question The workings of our minds and bodles, and of all the animate or lnanimate matter of which we have any detailed knowledges are as sumed to be controlled by the same set o£ fundamental laws which except under certain extreme conditions we f...

For a model of weakly coupled quantum Ising chains we outline the phase diagram and establish that well below the transition line the system has a remarkably one-dimensional spectrum. We study the dynamical magnetic susceptibility and find a very rich spectrum with several modes corresponding to a fundamental particle and its bound states. The approach is based on the Bethe ansatz and the rando...

Precipitative mixing experiments have been conducted with the aid of a turbidimeter and a darkfield microscope. The results of these experiments, correlated with observations of macroscopic features, indicate that serological precipitation is largely governed by a highly specific mechanism except in the terminal period, when the operation of non-specific forces becomes apparent. The findings ar...

In theoretical physics, paradoxes are good. That’s paradoxical, since a paradox appears to be a contradiction, and contradictions imply serious error. But Nature cannot realize contradictions. When our physical theories lead to paradox we must find a way out. Paradoxes focus our attention, and we think harder. When David Gross and I began the work that led to this Nobel Prize [1, 2, 3, 4], in 1...

In this research, plasma electrolytic oxidation coatings were prepared on AZ31 Mg alloy in a silicate-based solution containing K 2 TiF 6 using bipolar and soft sparking waveforms with 10, 20, 30% cathodic duty cycles. The displayed net-like surface morphology consisted of irregular micro-pores, micro-cracks, fused oxide particles, sintered structure. Due to the incorporation TiO colloidal part...

statement of problem: recent clinical results for zirconia all-ceramic restorations have revealed that the fracture rate 6-15% of the zirconia framework is so low and the core of zirconia has high stability. however, chipping-off fractures of porcelain are the most common reason for failures of zirconia in the fixed partial dentures. objectives: the purpose of this study was to compare the shea...